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Found 212 with Last Name = 'collie' and Initial = 'gw'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023342(CHEMBL3334567)
Affinity DataIC50:  2nMAssay Description:Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023342(CHEMBL3334567)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50: >2.5nMAssay Description:Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50: <3nMAssay Description:Inhibition of BCOR peptide binding to human BCL6 expressed in Escherichia coli measured after 270 mins by BCOR ULight TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597108(CHEMBL5184251 | US20230287003, Example 1v)
Affinity DataIC50:  12nMAssay Description:Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate in...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522280(US11161839, Example 10a)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50546197(CHEMBL4755229)
Affinity DataIC50: <30nMAssay Description:Inhibition of BCOR peptide binding to human BCL6 expressed in Escherichia coli measured after 270 mins by BCOR ULight TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597098(CHEMBL5173162 | US20230287003, Example 6b)
Affinity DataIC50:  39nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549946(CHEMBL4796908)
Affinity DataIC50:  44nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50587565(CHEMBL5081226)
Affinity DataIC50:  46nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549945(CHEMBL4784342)
Affinity DataIC50:  48nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522284(US11161839, Example 10e)
Affinity DataIC50:  54nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549947(CHEMBL4749560)
Affinity DataIC50:  65nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522285(US11161839, Example 10f)
Affinity DataIC50:  73nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597100(CHEMBL5203649)
Affinity DataIC50:  78nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522286(US11161839, Example 10g)
Affinity DataIC50:  82nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511629(CHEMBL4559074)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50609348(CHEMBL5272595)
Affinity DataIC50:  90nMAssay Description:Inhibition of his-tagged c-MET D1228V mutant (1050 to 1346 residues) (unknown origin) by ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597103(CHEMBL5199127 | US20230287003, Example 6a)
Affinity DataIC50:  94nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511625(CHEMBL4574515)
Affinity DataIC50:  97nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511644(CHEMBL4465387)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597102(CHEMBL5178675 | US20230287003, Example 1a)
Affinity DataIC50:  130nMAssay Description:Inhibition of human N-terminal thioredoxin 6-His tagged BCL6 BTB domain (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 pe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549948(CHEMBL4792886)
Affinity DataIC50:  137nMAssay Description:Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522196(US11161839, Example 1a | US11161839, Example 1b)
Affinity DataIC50:  140nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511624(CHEMBL4476234)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511651(CHEMBL4458261)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522291(US11161839, Example 10l)
Affinity DataIC50:  200nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511653(CHEMBL4573672)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50597098(CHEMBL5173162 | US20230287003, Example 6b)
Affinity DataIC50:  210nMAssay Description:Inhibition of human C-terminal nanoLuc-tagged BCL6 expressed in HEK293T cells co-expressing HaloTagged-SMRT using NanoBRET furimazine as substrate in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  214nMAssay Description:Inhibition of c-MET D1228V mutant phosphorylation at Tyr1234/Tyr1235 residues in CRISPR/Cas9 modified human NCI-H1993 cells incubated for 4 hrs by HT...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50:  214nMAssay Description:Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50399540(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Affinity DataIC50:  214nMAssay Description:Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM28031(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Affinity DataIC50:  214nMAssay Description:Inhibition of c-MET D1228V mutant phosphorylation at Tyr1234/Tyr1235 residues in CRISPR/Cas9 modified human NCI-H1993 cells incubated for 4 hrs by HT...More data for this Ligand-Target Pair
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511645(CHEMBL4524719)
Affinity DataIC50:  230nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522235(US11161839, Example 3p)
Affinity DataIC50:  250nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511622(CHEMBL4451702)
Affinity DataIC50:  260nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511648(CHEMBL4463841)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511627(CHEMBL4587209)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522312(US11161839, Example 11i)
Affinity DataIC50:  320nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511628(CHEMBL4439574)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM522274(US11161839, Example 9l)
Affinity DataIC50:  350nMAssay Description:Inhibition of human BCL6 (5 to 129 residues) expressed in Escherichia coli BL21-AI using BCOR-AF633 peptide as substrate measured after 2 hrs by TR-F...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
TBA

Curated by ChEMBL
LigandPNGBDBM50511630(CHEMBL4466680)
Affinity DataIC50:  390nMAssay Description:Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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