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Found 219 with Last Name = 'tarazi' and Initial = 'h'
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of CYP2D6 (unknown origin) using EOMCC as a substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BOMCC as a substrate incubated for 20 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of ErbB4 in human T47D cells assessed as suppression of neuregulin 1-induced autophosphorylation incubated for 90 mins by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  7nMAssay Description:Inhibition of c-Raf (unknown origin) in presence of ATP by hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530154(CHEMBL4440394)
Affinity DataIC50:  7nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530154(CHEMBL4440394)
Affinity DataIC50:  7nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50085415(3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-d...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530149(CHEMBL4457746)
Affinity DataIC50:  14nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530149(CHEMBL4457746)
Affinity DataIC50:  14nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50574707(CHEMBL4860202)
Affinity DataIC50:  15nMAssay Description:Inhibition of ErbB4 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50574708(CHEMBL4866102)
Affinity DataIC50:  18nMAssay Description:Inhibition of ErbB4 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50504170(CHEMBL4553144)
Affinity DataIC50:  22nMAssay Description:Inhibition of human p38alpha using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human ERG incubated for 3 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530158(CHEMBL4516769)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530158(CHEMBL4516769)
Affinity DataIC50:  26nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530155(CHEMBL4467188)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530155(CHEMBL4467188)
Affinity DataIC50:  30nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Flt4 (unknown origin) in presence of [gamma33]-ATP by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530147(CHEMBL4474427)
Affinity DataIC50:  38nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530147(CHEMBL4474427)
Affinity DataIC50:  38nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50117930((4-{1-[2-(6-Methyl-pyridin-2-yl)-ethyl]-piperidine...)
Affinity DataIC50:  43nMAssay Description:Inhibition of hERG measured by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530159(CHEMBL4463911)
Affinity DataIC50:  45nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530159(CHEMBL4463911)
Affinity DataIC50:  45nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530150(CHEMBL4552361)
Affinity DataIC50:  47nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50530150(CHEMBL4552361)
Affinity DataIC50:  47nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate measured after 40 mins in presence of [gamma33P-ATP] by scintillation c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  55nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BOMCC as a substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50591872(CHEMBL5202188)
Affinity DataIC50:  67nMAssay Description:Inhibition of c-Raf (unknown origin) in presence of ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  73nMAssay Description:Inhibition of JNK3 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259806(CHEMBL4100768)
Affinity DataIC50:  75nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50591873(CHEMBL5189396)
Affinity DataIC50:  82nMAssay Description:Inhibition of c-Raf (unknown origin) in presence of ATP by hotspot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259804(CHEMBL4075051)
Affinity DataIC50:  85nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM16018(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)
Affinity DataIC50:  91nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Affinity DataIC50:  92nMAssay Description:Inhibition of KDR (unknown origin) in presence of [gamma33]-ATP by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50562672(CHEMBL4797840)
Affinity DataIC50:  96nMAssay Description:Inhibition of Flt4 (unknown origin) in presence of [gamma33]-ATP by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50592452(CHEMBL5191468)
Affinity DataIC50:  97nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50592452(CHEMBL5191468)
Affinity DataIC50:  98nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259801(CHEMBL4092083)
Affinity DataIC50:  98nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50592449(CHEMBL5201911)
Affinity DataIC50:  99nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50232421(CHEMBL4100501)
Affinity DataIC50:  100nMAssay Description:Inhibition of human c-RAF using MEK1 as substrate in presence of [33P]ATP by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50592449(CHEMBL5201911)
Affinity DataIC50:  100nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259800(CHEMBL4062635)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259799(CHEMBL4078427)
Affinity DataIC50:  120nMAssay Description:Inhibition of BACE1 in human H4 cells expressing human APP K595N/M596L double mutant assessed as decrease in amyloid beta 42 and amyloid beta 40 leve...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50259797(CHEMBL4074001)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human BACE1 (1 to 460 residues) expressed in baculovirus infected insect cells using rhodamine-EVNLDAEFK peptide as substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Korea Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  138nMAssay Description:Inhibition of ErbB4 (unknown origin) incubated for 40 mins in presence of Mg/ATP mix by [gamma p33]-ATP based scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
University Of Sharjah

Curated by ChEMBL
LigandPNGBDBM50232423(CHEMBL4065090)
Affinity DataIC50:  150nMAssay Description:Inhibition of human c-RAF using MEK1 as substrate in presence of [33P]ATP by Hotspot assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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