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Found 606 with Last Name = 'york' and Initial = 'j'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107278(CHEMBL3600884)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107280(CHEMBL3600788)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  54nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107282(CHEMBL3600786)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107281(CHEMBL3600787)
Affinity DataKi:  129nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107279(CHEMBL3600883)
Affinity DataKi:  372nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107283(AAT-007 | CJ-023 | Grapiprant | MR-10A7 | RQ-00000...)
Affinity DataKi:  449nMAssay Description:Displacement of [3H]-PGE2 from recombinant human EP4 receptor expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  1.21E+3nMAssay Description:Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi:  1.55E+3nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.27E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP3 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.40E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.75E+4nMpH: 7.4Assay Description:hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genban...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM50446847(CHEMBL3115074)
Affinity DataKi: >1.75E+4nMAssay Description:Displacement of [3H]-PGE2 from human EP1 receptor by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)
Affinity DataKi:  4.13E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50028854(CHEMBL3342693)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194190(CHEMBL3956184)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194190(CHEMBL3956184)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233283(CHEMBL4102262)
Affinity DataIC50:  1nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233281(CHEMBL4084995)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233283(CHEMBL4102262)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233277(CHEMBL4085873)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233278(CHEMBL4064335)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233285(CHEMBL4101413)
Affinity DataIC50:  1nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50:  2nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194138(CHEMBL3928608)
Affinity DataIC50:  2nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194141(CHEMBL3938686)
Affinity DataIC50:  2nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in recombinant human interleukin-1 beta-induced PGE2 production preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50199773(3-(4-((R)-3-(4-chloro-2-(pyridin-2-yl)phenoxy)buto...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233276(CHEMBL4078000)
Affinity DataIC50:  2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233280(CHEMBL4063350)
Affinity DataIC50:  2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233284(CHEMBL4071976)
Affinity DataIC50:  2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233274(CHEMBL4067045)
Affinity DataIC50:  2nMAssay Description:Inhibition of human mPGES1 expressed in HEK293 microsomes assessed as reduction in PGE2 production using PGH2 as substrate after 2.5 mins by LC-MS an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50164242(6-(5-Phenyl-2-piperidin-4-yl-3H-imidazol-4-yl)-1-(...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50107278(CHEMBL3600884)
Affinity DataIC50:  2.90nMAssay Description:Antagonist activity at recombinant human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP accumulation by scinti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50199778(3-(4-((R)-3-(4-ethyl-2-(thiazol-4-yl)phenoxy)butox...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50227745(2-(4-(3-((2-bromo-4-(trifluoromethyl)benzamido)met...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50199776(3-(2-ethyl-4-((R)-3-(4-ethyl-2-(pyridin-2-yl)pheno...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50199779(3-(4-((R)-3-(4-ethyl-2-(pyridin-2-yl)phenoxy)butox...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194190(CHEMBL3956184)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in recombinant human interleukin-1 beta-induced PGE2 production preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194140(CHEMBL3947494)
Affinity DataIC50:  3nMAssay Description:Inhibition of human mPGES-1 expressed in 293E cells assessed as reduction in conversion of PGH2 to PGE2 after 1.5 min by LC/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50227761(2-(4-(3-fluoro-5-((2-fluoro-4-(trifluoromethyl)ben...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50227744(3-(4-(3-((5-chloro-1,3-dimethyl-1H-indole-2-carbox...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50227765(3-(4-(3-((5-chloro-3-methyl-1H-indole-2-carboxamid...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194627((R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)-2-me...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50194627((R)-3-(4-(3-(2-benzoyl-4-ethylphenoxy)butoxy)-2-me...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdelta by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233275(CHEMBL4094518)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50233277(CHEMBL4085873)
Affinity DataIC50:  3nMAssay Description:Inhibition of mPGES1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS addition meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50199781(3-(2-ethyl-4-((R)-3-(2-(pyridin-2-yl)-4-(trifluoro...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50227746(3-(4-(3-((5-chloro-1H-indole-2-carboxamido)methyl)...)
Affinity DataIC50:  3nMAssay Description:Displacement of [3H]-2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phenoxy)-2-methyl-butyric acid from human PPARdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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