Affinity DataKi: 0.0500nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.0600nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...More data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.0800nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.0900nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 0.100nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.130nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.140nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.190nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.210nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.220nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Binding affinity to human alpha3beta4 nAChRMore data for this Ligand-Target Pair
Affinity DataKi: 0.230nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.270nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.280nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.290nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.290nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.310nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.320nMAssay Description:Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.340nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.350nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.380nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
University Of Auckland
Curated by ChEMBL
University Of Auckland
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]nicotine from rat alpha4beta2 nAChR by liquid scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H4 receptor(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
Affinity DataKi: 0.400nMAssay Description:Displacement of [3H]histamine from recombinant human histamine H4 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.430nMAssay Description:In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamineMore data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair