Report error Found 3808 with Last Name = 'shaghafi' and Initial = 'm'
Affinity DataKi: 120nMAssay Description:Binding affinity to f7aMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+5nMAssay Description:Binding affinity to F9aMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+5nMAssay Description:Binding affinity to F9aMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 0.0700nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.0840nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.140nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.310nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.360nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.510nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.620nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.650nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.790nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 0.832nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 0.880nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.05nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.08nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.11nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.11nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.32nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.36nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.40nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.52nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.57nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.57nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 1.75nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full length N-terminal GST-tagged recombinant human MNK2 expressed in baculovirus expression system using Ac-TATKSGSTTKNR-NH2 as substr...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Effector Therapeutics
Curated by ChEMBL
Effector Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 2nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 4E-binding protein 1(Human)
Effector Therapeutics
US Patent
Effector Therapeutics
US Patent
Affinity DataIC50: 2.12nMAssay Description:eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...More data for this Ligand-Target Pair