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LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50302225((1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
LigandPNGBDBM50388871(CHEMBL2062931)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50334215((+/-)-threo-3-Iodomethylphenidate | CHEMBL1641691)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327143((R)-methyl 2-(4-aminophenyl)-2-((R)-piperidin-2-yl...)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388869(CHEMBL2062932)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50062915(CHEMBL827 | METHYLPHENIDATE | methyl (2R)-phenyl[(...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093443(CHEMBL3586683)
Affinity DataKi:  24nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50388870(CHEMBL2062933)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093442(CHEMBL3586682)
Affinity DataKi:  38nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50327141((R)-methyl 2-(4-nitrophenyl)-2-((R)-piperidin-2-yl...)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Human)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50093441(CHEMBL3586681)
Affinity DataKi:  227nMAssay Description:Inhibition of wild type human SERT expressed in HEK293 GripTite cells pre-incubated for 5 mins followed by [3H]5-HT addition by [3H]5-HT uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150059(CHEMBL183215 | N-(4-Methyl-2-pyrrolidin-1-yl-quino...)
Affinity DataIC50:  10nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150063(CHEMBL364863 | N-[4-Methyl-2-(4-methyl-piperazin-1...)
Affinity DataIC50:  63nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  71nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150064(CHEMBL182886 | N-(4-Methyl-2-morpholin-4-yl-quinol...)
Affinity DataIC50:  124nMAssay Description:Tested for MCH-1 induced [Ca2+] release from CHO cells transfected with human MCH-1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150072(2-(2,3-Dichloro-phenoxy)-N-[4-methyl-2-(4-methyl-p...)
Affinity DataIC50:  201nMAssay Description:Inhibitory activity against human 5-HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  349nMAssay Description:Inhibitory activity against human 5-HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150061(CHEMBL185376 | N-(2-Isopropylamino-4-methyl-quinol...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against human 5-HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150063(CHEMBL364863 | N-[4-Methyl-2-(4-methyl-piperazin-1...)
Affinity DataIC50:  442nMAssay Description:Inhibitory activity against human 5-HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  660nMAssay Description:Inhibition of human recombinant phospho-MK2 (36-400) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  700nMAssay Description:Displacement of [8-3H]ATP from human recombinant phospho-MK2 (36-400) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  970nMAssay Description:Inhibitory activity against human 5-HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  1.70E+3nMAssay Description:Displacement of [8-3H]ATP from human recombinant MK2 (36-400) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50150057(2-(4-Chloro-phenoxy)-N-[4-methyl-2-(4-methyl-piper...)
Affinity DataIC50:  2.18E+3nMAssay Description:Inhibitory activity against human 5-HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human recombinant phospho-MK2 (36-400) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  3.40E+3nMAssay Description:Displacement of [8-3H]ATP from human recombinant MK2 (41-364) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataIC50:  6.30E+3nMAssay Description:Displacement of [8-3H]ATP from human recombinant MK2 (36-400) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50366480(ADENOSINE TRIPHOSPHATE | ATP)
Affinity DataIC50:  1.20E+4nMAssay Description:Displacement of [8-3H]ATP from human recombinant MK2 (41-364) by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50316148(CK-2017357 | Tirasemtiv)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate in presence of NADPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed