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TargetHistone deacetylase(Human)
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405790(CHEMBL5284121)
Affinity DataIC50:  150nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405760(CHEMBL5284133)
Affinity DataIC50:  200nMAssay Description:Antagonist potency against muscarinic receptors was assed by antagonism of carbachol induced inhibition of electrically stimulated guinea pig atriaMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US20240131036,...)
Affinity DataIC50:  220nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339570(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Human)
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  500nMAssay Description:Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50:  600nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  680nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50539779(CHEMBL4647475)
Affinity DataIC50:  700nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339571(4-{4-[2'-(Naphthalen-1-yloxymethyl)-biphenyl-4-yl]...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant 5-lipooxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339572(4'-(1-Phenylsulfanylmethyl-1H-[1,2,3]triazol-4-yl)...)
Affinity DataIC50:  900nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  900nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500813(CHEMBL1087690)
Affinity DataIC50:  930nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500810(CHEMBL3758791)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386154(CHEMBL2042361)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Human)
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50480332(CHEMBL519853)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386163(CHEMBL2042367)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50539778(CHEMBL4636106)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50539781(CHEMBL4647634)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339573(4'-[1-(2-o-Tolyl-ethyl)-1H-[1,2,3]triazol-4-yl]-bi...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405791(CHEMBL5285589)
Affinity DataIC50:  1.70E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386163(CHEMBL2042367)
Affinity DataIC50:  1.96E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50577910(CHEMBL4866994)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-LO in A23187/AA-stimulated human intact neutrophils assessed as reduction in LTB4/5-HETE formation measured after 20 mins by RP-HPLC ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500817(CHEMBL3758432)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500816(CHEMBL3758656)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500809(CHEMBL3759529)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500815(CHEMBL3759699)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500812(CHEMBL3758253)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500814(CHEMBL1087807)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500811(CHEMBL3759749)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386154(CHEMBL2042361)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386164(CHEMBL2042366)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50500808(CHEMBL3758528)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386165(CHEMBL2042365)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50539780(CHEMBL4643829)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of mPGES1 in human A549 cells assessed as reduction in IL-1beta induced PGE2 release using PGH2 as substrate preincubated for 15 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339574(5-Dimethylamino-naphthalene-1-sulfonic acid{4'-[1-...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50405761(CHEMBL5274544)
Affinity DataIC50:  3.10E+3nMAssay Description:Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin E synthase 2(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of Prostaglandin E2 synthase-1 in IL-1beta stimulated microsomal fraction of human A549 cell assessed as PGE2 level by RP-HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50577910(CHEMBL4866994)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of mPGES-1 obtained from IL-beta stimulated human A549 cells microsomes assessed as residual activity by measuring conversion of PGH2 to P...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339574(5-Dimethylamino-naphthalene-1-sulfonic acid{4'-[1-...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of human recombinant 5-lipooxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Human)
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50480333(CHEMBL503268)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of HDAC in human SHSY5Y cells by fluorimetric cellular activity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386166(CHEMBL2042364)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386166(CHEMBL2042364)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386154(CHEMBL2042361)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophil preincubated for 15 mins before substrate arachidonic acid addition measured after 10 mins by HPLC m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386153(CHEMBL2042362)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of mPGES1 in IL-1beta-stimulated human A549 cell assessed as inhibition of PGE2 production preincubated for 15 mins before substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339576(4-(5-Benzyl-3-phenylsulfanylmethyl-3H-[1,2,3]triaz...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of 5-lipoxygenase in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50386159(CHEMBL2042356)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase in cell-free system preincubated for 10 mins before substrate arachidonic acid addition measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
University of Salerno

Curated by ChEMBL
LigandPNGBDBM50339575(4-(4-Biphenyl-4-yl-[1,2,3]triazol-1-ylmethyl)-3-ni...)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of human recombinant 5-lipooxygenase expressed in Escherichia coli MV1190 by cell free assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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