Report error Found 362 with Last Name = 'rossio' and Initial = 'p'
Affinity DataIC50: 1.30nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluor...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.80nMAssay Description:The experiments were carried out on the FLIPR TETRA.RTM. platform from Molecular Devices. After the basal level had been read, the compounds were add...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluor...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.10nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP12 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 37°CAssay Description:⿿PathHunter HEK293-CXCR2 or ⿿U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMT: 37°CAssay Description:⿿PathHunter HEK293-CXCR2 or ⿿U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of TACE in human PBMC assessed as reduction in LPS-induced TNFalpha production incubated overnight by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMT: 37°CAssay Description:⿿PathHunter HEK293-CXCR2 or ⿿U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMT: 37°CAssay Description:⿿PathHunter HEK293-CXCR2 or ⿿U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgamma (unknown origin) expressed in human HeLa-derived HG5LN cells transfected with the GAL4 DNA-binding domain fused ...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of antiCD-28 antibody stimulated IL-17A production after 4 days by ...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
Nestle Skin Health
Curated by ChEMBL
Nestle Skin Health
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at RORgamma in human CD4+ T cells assessed as inhibition of antiCD-28 antibody stimulated IL-17A production after 4 days by ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:The in vitro affinity of the compounds of the present invention for the CXCR1 and CXCR2 receptors was determined on a functional test of the β-a...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMT: 37°CAssay Description:⿿PathHunter HEK293-CXCR2 or ⿿U2OS hCXCR1 β-arrestin cells (DiscoveRx Corporation) were seeded overnight at 10 000 cells/well (384-well...More data for this Ligand-Target Pair
