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Found 148 with Last Name = 'hegde' and Initial = 'r'
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataKi:  0.600nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.60nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.80nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  72nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366495((+)butaclamol | CHEMBL1255588)
Affinity DataKi:  185nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  250nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291683(1-(3,4-Dihydroxy-benzyl)-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  350nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataKi:  500nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450614(CHEMBL2303762)
Affinity DataKi:  1.20E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291683(1-(3,4-Dihydroxy-benzyl)-2-methyl-1,2,3,4-tetrahyd...)
Affinity DataKi:  1.90E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50027331(1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquino...)
Affinity DataKi:  2.50E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50242856((1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  3.10E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50027331(1-(3,4-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquino...)
Affinity DataKi:  3.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50242856((1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquin...)
Affinity DataKi:  3.90E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120316(CHEMBL2367887 | Triterpene Glycoside analogue)
Affinity DataKi:  5.10E+3nMAssay Description:Inhibitory activity of the compound against human CCR5 chemokine receptor (CCR5) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291684(1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  5.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291684(1-Methyl-1,2,3,4-tetrahydro-isoquinoline-6,7-diol ...)
Affinity DataKi:  6.40E+3nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataKi:  9.40E+3nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50450614(CHEMBL2303762)
Affinity DataKi:  1.14E+4nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Affinity DataKi: >1.70E+4nMAssay Description:Potency was measured by the displacement of [3H]spiperone binding to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120315(CHEMBL2367888 | Triterpene Glycoside analogue)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibitory activity of the compound against human CCR5 chemokine receptor (CCR5) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM29135(CHEMBL11608 | cid_5610 | p-Tyramine | tyramine)
Affinity DataKi: >3.50E+4nMAssay Description:Potency was measured by the displacement of [3H]-spiperone binding to human D4 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  6nMAssay Description:Displacement of QNB from muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  7nMAssay Description:Displacement of QNB from muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292438(1,-(4-amino-5-oxotridecane-1,13-diyl)diguanidine |...)
Affinity DataIC50:  10nMAssay Description:Displacement of QNB from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306888(4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306874(8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50366855(CHEMBL525803 | Chloropeptin)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50123450(CHEMBL3143464 | Chloropeptin I analogue)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetT-cell surface glycoprotein CD4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50123449(CHEMBL437996 | Chloropeptin II | ISOCOMPLESTATIN)
Affinity DataIC50:  130nMAssay Description:Inhibitory concentration against CD4-gp120 binding in the absence of fetal bovine serum (FBS); Range is 0.13-0.5 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  140nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306888(4,6-dimethoxy-3-methyl-1H-pyrazolo[3,4-b]quinoline...)
Affinity DataIC50:  200nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306874(8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[...)
Affinity DataIC50:  214nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  214nMAssay Description:Inhibition of CDC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50070315((3S,9S)-9-Benzyl-3-isobutyl-6-methyl-13-(1-methyl-...)
Affinity DataIC50:  300nMAssay Description:Compound was evaluated for inhibitory activity against cholesteryl ester transfer proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50135740(2,3,4,5,6,7,14,15-octahydroxy-13-(5-hydroxy-4-oxo-...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity of the compound evaluated in the HCV NS3 protease activity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50135739(13-[3,5-dihydroxy-4-(3-phenylpropanoyl)phenoxy]-2,...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity of the compound evaluated in the HCV NS3 protease assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  910nMAssay Description:Displacement of QNB from muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  960nMAssay Description:Displacement of QNB from muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291681(2,3-Dihydro-1H-indol-5-ol | CHEMBL19331)
Affinity DataIC50:  1.03E+3nMAssay Description:Inhibitory concentration against binding of [3H]spiperone to human D2 dopaminergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306869(8-Methoxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50292439(CHEMBL479224 | N-(1,13-diguanidino-5-oxotridecan-4...)
Affinity DataIC50:  1.41E+3nMAssay Description:Displacement of QNB from muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306874(8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  1.42E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50197834(2,9-dihydroxy-1-methoxydibenzo[cd,f]indol-4(5H)-on...)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of Aurora 2 kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306874(8-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo[...)
Affinity DataIC50:  2.14E+3nMAssay Description:Inhibition of AUR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50306877(10-Hydroxy-6H-benzo[f][1,3]dioxolo[4',5':4,5]benzo...)
Affinity DataIC50:  2.15E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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