Compile Data Set for Download or QSAR
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Found 614 with Last Name = 'xiang' and Initial = 's'
TargetThreonine--tRNA ligase(Phytophthora sojae)
Northeast Agricultural University

Curated by ChEMBL
LigandPNGBDBM50129555((1R,2R)-2-((4E,6Z)-(2S,8R,9S,11R,13S,15S,16S)-7-cy...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of C-terminal His6-tagged Phytophthora sojae race 1 recombinant ThrRS expressed in Escherichia coli BL21 (Codonplus DE3) assessed as reduc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of FGFR2 V564M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human RET V804L mutantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human RET V804M mutantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173235((S)-2-{4'-[(5-Bromo-4-methoxy-benzofuran-2-carbony...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human wild type RETMore data for this Ligand-Target Pair
LigandPNGBDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human wild type RETMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human RET V804L mutantMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild type FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))TBA
LigandPNGBDBM50604182(CHEMBL5194425)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wild type FGFR4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50:  0.5nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of FGFR1 V561M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173236((S)-2-{4'-[(5-Bromo-benzofuran-2-carbonyl)-amino]-...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM296429(US10112942, Example 163 | US10112942, Example 166 ...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human RET V804M mutantMore data for this Ligand-Target Pair
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394660(US10308615, Example 17 | preparation of [3-(methyl...)
Affinity DataIC50:  0.800nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173236((S)-2-{4'-[(5-Bromo-benzofuran-2-carbonyl)-amino]-...)
Affinity DataIC50:  0.910nMAssay Description:Inhibitory concentration against MMP-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50459416(CHEMBL4216473)
Affinity DataIC50:  1nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM395062((2-{[(6- methylpyridin-3- yl)methyl]amino} pyrimid...)
Affinity DataIC50:  1.20nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259007((R)-2-(4'-((4-isobutyrylphenoxy)methyl)biphenyl-4-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM395062((2-{[(6- methylpyridin-3- yl)methyl]amino} pyrimid...)
Affinity DataIC50:  1.70nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394659(US10308615, Example 16 | preparation of (2-{[1-(py...)
Affinity DataIC50:  1.70nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin)More data for this Ligand-Target Pair
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394660(US10308615, Example 17 | preparation of [3-(methyl...)
Affinity DataIC50:  1.80nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50:  1.90nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173220((S)-2-{4'-[(5-Chloro-4-methoxy-3-methyl-benzofuran...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of wild type FGFR3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394656(US10308615, Example 13 | [3-(methylsulfonyl)phenyl...)
Affinity DataIC50:  2nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of TRKA G595R mutant (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394645(3-[(2-{[1-(pyridin-3-yl)cyclopropyl]amino}pyrimidi...)
Affinity DataIC50:  2.10nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50189781(CHEMBL3828009)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173218((S)-2-{4'-[(5-Iodo-4-methoxy-3-methyl-benzofuran-2...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50259009((R)-3-methyl-2-(4'-((5-oxo-5,6,7,8-tetrahydronapht...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173223((S)-2-(4'-(5-bromo-4-methoxy-3-methylbenzofuran-2-...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50170298((S)-2-{4'-[(4-Methoxy-benzofuran-2-carbonyl)-amino...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of TRKC (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 50 uM ATP by FRET based Z'-Lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM24043((2R)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394659(US10308615, Example 16 | preparation of (2-{[1-(py...)
Affinity DataIC50:  2.60nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM136597(US10005783, 14 | US10047097, 14 | US10774085, Exam...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of N-terminal hexahistidine tagged TRKA (485 to 795 residues) (unknown origin) expressed in Sf9 cells using Ser/Thr 06 peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605160(CHEMBL5184321)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) using Ser/Thr 06 peptide as substrate incubated for 1 hr in presence of 400 uM ATP by FRET based Z'-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50:  2.90nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173229((S)-2-{4'-[(5-Cyano-4-methoxy-3-methyl-benzofuran-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))TBA
LigandPNGBDBM50459416(CHEMBL4216473)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type KIT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50173224((S)-2-{4'-[(5-Bromo-3-methyl-benzofuran-2-carbonyl...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50507492(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal hexahistidine tagged TRKA (485 to 795 residues) (unknown origin) expressed in Sf9 cells using Ser/Thr 06 peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Jinan University

Curated by ChEMBL
LigandPNGBDBM50605159(CHEMBL5195469)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of CD74 fused TRKA G667C mutant (unknown origin) expressed in mouse BaF3 cells assessed as inhibition of PLCgamma1 phosphorylation incubat...More data for this Ligand-Target Pair
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