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Found 669 with Last Name = 'heckrodt' and Initial = 't'
TargetCytochrome P450 1A2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593319(CHEMBL5188333)
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589401(CHEMBL5169945)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589421(CHEMBL5187995)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant GST-tagged JAK1 catalytic domain (866 to 1154 residues) expressed in baculovirus expression system by Z'-lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589432(CHEMBL5178313)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589397(CHEMBL5185144)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589400(CHEMBL5175590)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589414(CHEMBL5192205)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269383(CHEMBL4090562)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589424(CHEMBL5187663)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313069(1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313084(1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Affinity DataIC50:  3nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589418(CHEMBL5183959)
Affinity DataIC50:  3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589417(CHEMBL5198583)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589420(CHEMBL5181320)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269393(CHEMBL4078564)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589423(CHEMBL5175829)
Affinity DataIC50:  4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589431(CHEMBL5200765)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589433(CHEMBL5193503)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589425(CHEMBL5208062)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589428(CHEMBL5207689)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589426(CHEMBL5178272)
Affinity DataIC50:  5nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589419(CHEMBL5184745)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589399(CHEMBL5201935)
Affinity DataIC50:  6nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM313027(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589406(CHEMBL5188095)
Affinity DataIC50:  7nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  8nMAssay Description:Inhibition of JAK1/TYK2 signaling pathway in human primary T-cells assessed as reduction of IFN-alpha induced STAT1 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589416(CHEMBL5177543)
Affinity DataIC50:  8nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589429(CHEMBL5173098)
Affinity DataIC50:  9nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593315(CHEMBL5209379)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269392(CHEMBL4068447)
Affinity DataIC50:  9nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Axl (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269391(CHEMBL4059790)
Affinity DataIC50:  9nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593316(CHEMBL5170161)
Affinity DataIC50:  9nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589396(CHEMBL5170107)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269394(CHEMBL4095789)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589405(CHEMBL5170085)
Affinity DataIC50:  10nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593304(CHEMBL5191312)
Affinity DataIC50:  11nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589415(CHEMBL5189048)
Affinity DataIC50:  11nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589407(CHEMBL5179113)
Affinity DataIC50:  12nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589408(CHEMBL5185436)
Affinity DataIC50:  12nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetJAK3/JAK1(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593318(CHEMBL5187209)
Affinity DataIC50:  12nMAssay Description:Inhibition of JAK1/JAK3 in human primary T-cells assessed as reduction of IL-2 stimulated STAT5 phosphorylation preincubated for 1 hr followed by IL-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged TYK2 (833 to 1187 residues) expressed in baculovirus expression system by Z'-lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50593320(A-301 | ATI-502 | Ati-502 | IFIDANCITINIB | Ifidan...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant GST-tagged JAK2 catalytic domain (809 to 1153 residues) expressed in baculovirus expression system by Z'-lyte assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269375(CHEMBL4086420)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589398(CHEMBL5184991)
Affinity DataIC50:  14nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50589403(CHEMBL5178542)
Affinity DataIC50:  15nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50269395(CHEMBL4101639)
Affinity DataIC50:  15nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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