TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 0.0540nMAssay Description:Inhibitory constant for RTX binding to rat spinal cordMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 0.120nMAssay Description:Inhibitory constant for RTX binding to porcine spinal cordMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 0.450nMAssay Description:Inhibitory constant for RTX binding to human spinal cordMore data for this Ligand-Target Pair
Affinity DataKi: 0.450nM ΔG°: -54.2kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Displacement of [3H]-CP-55,940 from human recombinant CB2 receptor expressed in HEK293 cells membrane incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 7.5nM ΔG°: -47.2kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
Affinity DataKi: 9.20nMAssay Description:Displacement of [3H]-CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cells membrane incubated for 90 minsMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: <10nMAssay Description:Agonistic activity against vanilloid receptor 1 (TRPV1)More data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -46.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 11nM ΔG°: -46.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 13nM ΔG°: -45.8kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
Affinity DataKi: 14nM ΔG°: -45.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 20nM ΔG°: -44.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor transfected in CHO cells measured for 1.5 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Universit£
Curated by ChEMBL
Universit£
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Displacement of [3H]SR12813 from human PXR by scintillation proximity competition binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 27nM ΔG°: -43.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 28nM ΔG°: -43.8kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 32nM ΔG°: -43.5kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 47nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor transfected in CHO cells measured for 1.5 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 70nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
Affinity DataKi: 81nMAssay Description:Binding affinity to human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
Affinity DataKi: 99nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor transfected in CHO cells measured for 1.5 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 150nM ΔG°: -39.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 168nM ΔG°: -39.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Binding affinity to human recombinant CB2 receptor expressed in COS cellsMore data for this Ligand-Target Pair
Affinity DataKi: 180nMAssay Description:Displacement of [3H]-CP-55,940 from human recombinant CB2 receptor expressed in HEK293 cells membrane incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 190nM ΔG°: -39.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
Affinity DataKi: 200nM ΔG°: -38.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 228nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor transfected in CHO cells measured for 1.5 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 240nM ΔG°: -38.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
Affinity DataKi: 340nM ΔG°: -37.5kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 380nM ΔG°: -37.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 400nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
Affinity DataKi: 470nMAssay Description:Binding affinity to human recombinant CB1 receptor expressed in COS cellsMore data for this Ligand-Target Pair
Affinity DataKi: 570nM ΔG°: -36.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute
Curated by ChEMBL
Institute
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Displacement of [3H]RTX binding from Vanilloid receptor of rat dorsal Root Ganglion (DRG) membranesMore data for this Ligand-Target Pair
Affinity DataKi: 600nM ΔG°: -36.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 680nM ΔG°: -35.8kJ/molepH: 7.4 T: 2°CAssay Description:In this assay, 18 ug of crude membrane expressing hCB1 or hCB2 receptors were re-suspended in 300 uL of binding buffer containing 50 mM Tris-HCl, 2.5...More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -35.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -35.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Affinity DataKi: 750nMAssay Description:Displacement of [3H]-CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cells membrane incubated for 90 minsMore data for this Ligand-Target Pair