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Found 106 with Last Name = 'arora' and Initial = 'r'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553686(CHEMBL4782133)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50553677(CHEMBL4797516)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50:  13nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107393(CHEMBL3601472)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107389(CHEMBL3601476)
Affinity DataIC50:  20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553686(CHEMBL4782133)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50107387(CHEMBL3601478)
Affinity DataIC50:  30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataIC50:  31nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107381(CHEMBL3601465)
Affinity DataIC50:  50nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50:  60nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151848(CHEMBL3774827)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151845(CHEMBL3775504)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151730(CHEMBL3775985)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151847(CHEMBL3775875)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151755(CHEMBL3775119)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151754(CHEMBL3775230)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107394(CHEMBL3601471)
Affinity DataIC50:  80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50107380(CHEMBL3601466)
Affinity DataIC50:  90nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107384(CHEMBL3601895)
Affinity DataIC50:  90nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075578(CHEMBL3415553)
Affinity DataIC50:  100nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075577(CHEMBL3415556)
Affinity DataIC50: <100nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151846(CHEMBL3774677)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075581(CHEMBL3415555)
Affinity DataIC50: <100nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107385(CHEMBL3601894)
Affinity DataIC50:  110nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107391(CHEMBL3601474)
Affinity DataIC50:  110nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553687(CHEMBL4760736)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50:  160nMAssay Description:Inhibition of wild type B-Raf (unknown origin) assessed as inhibition of phosphorylation of peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151729(CHEMBL3775200)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151728(CHEMBL3774605)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553679(CHEMBL4793302)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50553679(CHEMBL4793302)
Affinity DataIC50:  210nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Sphaera Pharma

Curated by ChEMBL
LigandPNGBDBM50553684(CHEMBL4764922)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50107379(CHEMBL3601467)
Affinity DataIC50:  230nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151756(CHEMBL3774843)
Affinity DataIC50:  270nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553678(CHEMBL4789524)
Affinity DataIC50:  270nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50107390(CHEMBL3601475)
Affinity DataIC50:  270nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107386(CHEMBL3601479)
Affinity DataIC50:  290nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107392(CHEMBL3601473)
Affinity DataIC50:  320nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50107377(CHEMBL3601469)
Affinity DataIC50:  330nMAssay Description:Inhibition of PI3Kalpha (unknown origin) after 60 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151727(CHEMBL3774899)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553680(CHEMBL4783100)
Affinity DataIC50:  460nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50151711(CHEMBL3775032)
Affinity DataIC50:  540nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50553683(CHEMBL4762830)
Affinity DataIC50:  560nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged p110 alpha/p85 alpha expressed in baculovirus expression system using PIP2 as subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50151726(CHEMBL3775133)
Affinity DataIC50:  600nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151713(CHEMBL3775646)
Affinity DataIC50:  680nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151710(CHEMBL3775745)
Affinity DataIC50:  730nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151700(CHEMBL3774579)
Affinity DataIC50:  740nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Umr Cnrs-Universit£

Curated by ChEMBL
LigandPNGBDBM50075576(CHEMBL3415554)
Affinity DataIC50: <800nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50151849(CHEMBL3774907)
Affinity DataIC50:  800nMAssay Description:Inhibition of human recombinant PI3K-alpha using phosphatidylinositol biphosphate as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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