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Found 1030 with Last Name = 'barnes' and Initial = 'd'
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451155(US10676499, Example 49)
Affinity DataKi:  20nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451159(US10676499, Example 57)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451145(US10676499, Example 17)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451148(US10676499, Example 29)
Affinity DataKi:  30nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKi:  40nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451147(US10676499, Example 26)
Affinity DataKi:  50nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451144(US10676499, Example 1)
Affinity DataKi:  100nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451150(US10676499, Example 33)
Affinity DataKi:  170nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451146(US10676499, Example 18)
Affinity DataKi:  180nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451156(US10676499, Example 53)
Affinity DataKi:  190nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113399(4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-...)
Affinity DataKi:  423nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM249466(US10072016, Compound 65 | US10407433, Compound 65 ...)
Affinity DataKi:  720nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes assessed as equilibrium inhibition binding constant in presence of NADPH by LC-MS/MS an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451160(US10676499, Example 58)
Affinity DataKi:  1.00E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113373(2-Cyclopentyloxy-4-(1,2-diphenyl-ethyl)-1-methoxy-...)
Affinity DataKi:  1.17E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451151(US10676499, Example 40)
Affinity DataKi:  2.36E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451157(US10676499, Example 54)
Affinity DataKi:  2.78E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Albany College Of Pharmacy And Health Sciences

Curated by ChEMBL
LigandPNGBDBM50501900(CHEMBL4463039)
Affinity DataKi:  3.13E+3nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes assessed as equilibrium inhibition binding constant in presence of NADPH by LC-MS/MS an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451154(US10676499, Example 43)
Affinity DataKi:  3.17E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451153(US10676499, Example 42)
Affinity DataKi:  4.90E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Celltech R&D

Curated by ChEMBL
LigandPNGBDBM50113366(4-[2-(3-Cyclopentyloxy-4-methoxy-phenyl)-2-phenyl-...)
Affinity DataKi: >8.00E+3nMAssay Description:Inhibition of human recombinant phosphodiesterase 4AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451152(US10676499, Example 41)
Affinity DataKi:  8.82E+3nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451149(US10676499, Example 32)
Affinity DataKi:  9.36E+4nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM50378304(CHEMBL568080)
Affinity DataIC50: <0.0300nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378288(CHEMBL567434)
Affinity DataIC50:  0.0300nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378289(CHEMBL565705)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378319(CHEMBL568303)
Affinity DataIC50: <0.0400nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378290(CHEMBL568310)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378305(CHEMBL583417)
Affinity DataIC50: <0.0400nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378291(CHEMBL568302)
Affinity DataIC50:  0.0400nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378292(CHEMBL566106)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50003691(CHEMBL567624)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003691(CHEMBL567624)
Affinity DataIC50: <0.0500nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378293(CHEMBL566550)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378294(CHEMBL566972)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378292(CHEMBL566106)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378295(CHEMBL565490)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378290(CHEMBL568310)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378298(CHEMBL583421)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378299(CHEMBL568079)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378296(CHEMBL568510)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378297(CHEMBL566105)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378288(CHEMBL567434)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378303(CHEMBL567208)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378302(CHEMBL583615)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378305(CHEMBL583417)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378304(CHEMBL568080)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378212(CHEMBL575450)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50378300(CHEMBL565930)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Cdk2/cyclinEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378297(CHEMBL566105)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM50378289(CHEMBL565705)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant Cdk2/cyclinAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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