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Found 1217 with Last Name = 'bauer' and Initial = 'a'
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12396(1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3...)
Affinity DataKi:  0.0700nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12389(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.100nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264960(CHEMBL4089819)
Affinity DataKi:  0.200nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12387(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.25nM ΔG°:  -54.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12395(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  0.300nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM109847(US8609681, 70)
Affinity DataKi:  0.300nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264892(CHEMBL4065072)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265119(CHEMBL4091099)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264892(CHEMBL4065072)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264931(CHEMBL4084457)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265083(CHEMBL4100996)
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265119(CHEMBL4091099)
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265344(CHEMBL4070237)
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM109859(US8609681, 102)
Affinity DataKi:  0.5nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM50590085(CHEMBL5187102)
Affinity DataKi:  0.5nMAssay Description:Inhibition of human fXa assessed as inhibition constant using Cbz-D-Arg-Gly-L-Arg-pNA as substrate preincubated for 30 mins followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265083(CHEMBL4100996)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265384(CHEMBL4104777)
Affinity DataKi:  0.600nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12384(2-Carboxyindole Scaffold 35 | 7-Chloro-1-[5-(5-chl...)
Affinity DataKi:  0.700nM ΔG°:  -52.3kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264960(CHEMBL4089819)
Affinity DataKi:  0.700nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265344(CHEMBL4070237)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264931(CHEMBL4084457)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264941(CHEMBL4063327)
Affinity DataKi:  0.900nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12388(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  1nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM109858(US8609681, 97)
Affinity DataKi:  1nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265130(CHEMBL4064275)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12381(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM15867(1-{[(5-chloropyridin-2-yl)carbamoyl]methyl}-N-[1-(...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265090(CHEMBL4101304)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265091(CHEMBL4083310)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264971(CHEMBL4089913)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265384(CHEMBL4104777)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265145(CHEMBL4073661)
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265185(CHEMBL4092088)
Affinity DataKi:  1.40nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265141(CHEMBL4094478)
Affinity DataKi:  1.5nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265328(CHEMBL4087970)
Affinity DataKi:  1.5nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265091(CHEMBL4083310)
Affinity DataKi:  1.5nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264955(CHEMBL4099961)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265130(CHEMBL4064275)
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265045(CHEMBL4097940)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265145(CHEMBL4073661)
Affinity DataKi:  1.80nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM109862(US8609681, 9)
Affinity DataKi:  1.80nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin K. This protein is obtained as an inactive enzyme from Sanofi-Aven...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12390(1-[5-(5-Chlorothiophen-2-yl)isoxazol-3-ylmethyl]-3...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM109839(US8609681, 36)
Affinity DataKi:  2nMAssay Description:Determination of the enzymatic activity of the catalytic domain of human Cathepsin S. This protein is obtained as an inactive enzyme from R&D Systems...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12392(2-Carboxyindole Scaffold 24 | 3-Bromo-1-[5-(5-chlo...)
Affinity DataKi:  2nMAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264941(CHEMBL4063327)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50264969(CHEMBL4096348)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265048(CHEMBL4065627)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265000(CHEMBL4101342)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 6(Homo sapiens (Human))
University Of Gdansk

Curated by ChEMBL
LigandPNGBDBM50265131(CHEMBL4093570)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human PACE4 expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Aventis Pharma

LigandPNGBDBM12379(1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrates S-2765. The hydrolysis rates of chromogenic s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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