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Found 243 with Last Name = 'benedetti' and Initial = 'r'
TargetTransporter(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  0.135nMAssay Description:Displacement of [N-methyl-3H]nisoxetine from rat hippocampus NET by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(MOUSE)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  0.851nMAssay Description:Displacement of [3H]citalopram from mouse cortex SERT by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(MOUSE)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]-citalopram from SERT in mouse cortex after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(MOUSE)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]nisoxetine from NET in mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransporter(Rattus norvegicus (rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]nisoxetine from NET in rat hippocampus after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(MOUSE)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50322698(rel-1-(3,4-dichlorophenyl)-6-(methoxymethyl)-3-aza...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]WIN-35428 from DAT in mouse brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50308250((1R,5R,6R)-1-(3,4-dichlorophenyl)-6-(ethoxymethyl)...)
Affinity DataKi:  1.26E+4nMAssay Description:from Dfrom ifrom sfrom pfrom lfrom afrom cfrom efrom mfrom efrom nfrom tfrom from ofrom ffrom from [from 3from Hfrom ]from dfrom ofrom ffrom efrom tf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591852(CHEMBL5188540)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483163(CHEMBL1630067)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483149(CHEMBL1630065)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483151(CHEMBL1630068)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483150(CHEMBL1630066)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483155(CHEMBL1630076)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591853(CHEMBL5176595)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409064(CHEMBL5269954)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM26119(2-[4-(methoxycarbonyl)pyridin-2-yl]pyridine-4-carb...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant JARID1C (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Mus musculus)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483144(CHEMBL1630057 | GSK2210875)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Mus musculus)
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483145(CHEMBL1630080)
Affinity DataIC50:  32nMAssay Description:Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))TBA
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  33nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483145(CHEMBL1630080)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483153(CHEMBL1630070)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483152(CHEMBL1630069)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483147(CHEMBL1630061)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483144(CHEMBL1630057 | GSK2210875)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591850(CHEMBL5184498)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483160(CHEMBL1630064)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409203(CHEMBL5289038)
Affinity DataIC50:  61nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483157(CHEMBL1630079)
Affinity DataIC50:  63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483146(CHEMBL1630059)
Affinity DataIC50:  63nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409199(CHEMBL5280583)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50495468(CHEMBL3108958)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant JMJD2C (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409198(CHEMBL5276531)
Affinity DataIC50:  71nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409059(CHEMBL5282958)
Affinity DataIC50:  73nMAssay Description:Antagonist activity at Alpha-1D adrenoceptor in Wistar rat thoracic aorta assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409190(CHEMBL5281527)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at 5-HT3 receptor in guinea pig ileum muscleMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591851(CHEMBL5189806)
Affinity DataIC50:  91nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591852(CHEMBL5188540)
Affinity DataIC50:  99nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409061(CHEMBL5276825)
Affinity DataIC50:  111nMAssay Description:Antagonist activity at Alpha-1B adrenoceptor in Wistar rat spleen assessed as phenylephrine induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409187(CHEMBL5290574)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591851(CHEMBL5189806)
Affinity DataIC50:  113nMAssay Description:Inhibition of recombinant human HDAC8 using FLUOR DE LYS as substrate preincubated for 15 mins followed by substrate addition measured after 1 hrs by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591849(CHEMBL5181949)
Affinity DataIC50:  121nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50483158(CHEMBL1630077)
Affinity DataIC50:  126nMAssay Description:Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilizationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50591856(CHEMBL5177483)
Affinity DataIC50:  130nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 cells using ZMAL (Z-(Ac)Lys-AMC as substrate measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant JMJD3 (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50495468(CHEMBL3108958)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant JMJD1A (unknown origin) incubated for 15 mins prior to substrate addition by AlphaScreen methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
University Of Siena

Curated by ChEMBL
LigandPNGBDBM50409065(CHEMBL5280477)
Affinity DataIC50:  142nMAssay Description:Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferans assessed as noradrenaline induced contractions after 30 minsMore data for this Ligand-Target Pair
In DepthDetails PubMed
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