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Found 273 with Last Name = 'benson' and Initial = 'e'
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196751(CHEMBL231862 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  1nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196755(CHEMBL266567 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238434(CHEMBL4098952)
Affinity DataIC50:  2nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196746(CHEMBL231861 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196747(CHEMBL266566 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210717(CHEMBL397275 | N1-((2S,3R)-4-(3-ethylbenzylamino)-...)
Affinity DataIC50:  2nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238419(CHEMBL4060134)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196736(CHEMBL231863 | benzyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196749(CHEMBL394270 | pyridin-4-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196745(CHEMBL414145 | methyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196733(CHEMBL414776 | pyridin-3-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238417(CHEMBL4094551)
Affinity DataIC50:  4nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196754(CHEMBL393733 | methyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196757(CHEMBL391144 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196744(2,2,2-trifluoroethyl (S)-1-((2S,3R)-4-(3-ethylbenz...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196752(CHEMBL412852 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196740(CHEMBL409875 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196734(CHEMBL409947 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  4nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210721(CHEMBL397714 | N1-((2S,3R)-4-(3-ethylbenzylamino)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15797((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-i...)
Affinity DataIC50:  5nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15797((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-i...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant BACEMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196739(CHEMBL266531 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196750(CHEMBL394271 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196753(CHEMBL266565 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  5nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238433(CHEMBL4080918)
Affinity DataIC50:  6.30nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238434(CHEMBL4098952)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238448(CHEMBL4083872)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238449(CHEMBL4089774)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238418(CHEMBL4096094)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196758(2-cyanoethyl 1-((2S,3R)-4-(3-ethylbenzylamino)-1-(...)
Affinity DataIC50:  8nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196756(CHEMBL409949 | pyridin-3-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196731(CHEMBL231669 | N-{(S)-2-(butane-1-sulfonyl)-1-[(1S...)
Affinity DataIC50:  10nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238437(CHEMBL4068794)
Affinity DataIC50:  10nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238447(CHEMBL4101869)
Affinity DataIC50:  10nMAssay Description:Binding affinity against calf intestine adenosine deaminase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50210709(CHEMBL396765 | N1-((2S,3R)-4-(3-methoxybenzylamino...)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196743(CHEMBL409950 | pyridin-4-ylmethyl (S)-1-((2S,3R)-4...)
Affinity DataIC50:  11nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196741((S)-N-((2S,3R)-4-(3-ethylbenzylamino)-1-(3,5-diflu...)
Affinity DataIC50:  13nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196742(CHEMBL393140 | N-((S)-1-((2S,3R)-4-(3-ethylbenzyla...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196737(CHEMBL409948 | S-tetrahydrofuran-3-yl (S)-1-((2S,3...)
Affinity DataIC50:  15nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  16nMAssay Description:Inhibition of His-tagged TNKS1 (1091 to 1325 residues) (unknown origin) assessed as reduction in PARsylation of GST-tev-Axin2 preincubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238436(CHEMBL4079594)
Affinity DataIC50:  16nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238422(CHEMBL4098529)
Affinity DataIC50:  16nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196744(2,2,2-trifluoroethyl (S)-1-((2S,3R)-4-(3-ethylbenz...)
Affinity DataIC50:  19nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM15798((1S,2R)-N-[1-(3,5-Difluorobenzyl)-2-hydroxy-3-(3-m...)
Affinity DataIC50:  20nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238430(CHEMBL4096495)
Affinity DataIC50:  20nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238446(CHEMBL4073498)
Affinity DataIC50:  20nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238427(CHEMBL4066552)
Affinity DataIC50:  20nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  20nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50196736(CHEMBL231863 | benzyl (S)-1-((2S,3R)-4-(3-ethylben...)
Affinity DataIC50:  20nMAssay Description:Inhibition of cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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