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Found 722 with Last Name = 'bhattacharya' and Initial = 'a'
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254203(US10112937, Example 88 | US10150765, Example 88 | ...)
Affinity DataKi:  2.20nMAssay Description:Antagonist activity at recombinant rat P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
National Chemical Laboratory (Csir-Ncl)

Curated by ChEMBL
LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Affinity DataKi:  3.36nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254266(US10112937, Example 158 | US10150765, Example 158 ...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-A-804598 from recombinant rat P2X7 expressed in human 1321N1 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254266(US10112937, Example 158 | US10150765, Example 158 ...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-A-804598 from recombinant human P2X7 expressed in human 1321N1 cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254160(US10112937, Example 40 | US10150765, Example 40 | ...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254160(US10112937, Example 40 | US10150765, Example 40 | ...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254203(US10112937, Example 88 | US10150765, Example 88 | ...)
Affinity DataKi:  13nMAssay Description:Antagonist activity at recombinant human P2X7 expressed in human 1321N1 cells assessed as inhibition of BzATP-induced calcium flux preincubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50052442((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)
Affinity DataKi:  14nMAssay Description:Binding affinity to human recombinant TRPV1More data for this Ligand-Target Pair
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254296(US10112937, Example 193 | US10150765, Example 193 ...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
National Chemical Laboratory (Csir-Ncl)

Curated by ChEMBL
LigandPNGBDBM50364010(CHEMBL1950263)
Affinity DataKi:  23nMAssay Description:Inhibition of papaya papainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254164(US10112937, Example 44 | US10150765, Example 44 | ...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM254166(US10112937, Example 46 | US10150765, Example 46 | ...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-(S)-7-(2-chloro-3-(trifluoromethyl)benzyl)-6-methyl-3-(pyrazin-2-yl)-6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one from re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
National Chemical Laboratory (Csir-Ncl)

Curated by ChEMBL
LigandPNGBDBM50364010(CHEMBL1950263)
Affinity DataKi:  500nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558642(US11365202, Compound 3a)
Affinity DataKi:  2.49E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578419(CHEMBL4857262)
Affinity DataKi:  2.49E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578421(CHEMBL4850572)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558644(US11365202, Compound 5a)
Affinity DataKi:  2.60E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578417(CHEMBL4868442)
Affinity DataKi:  2.78E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558642(US11365202, Compound 3a)
Affinity DataKi:  2.78E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558638(US11365202, Compound 3)
Affinity DataKi:  3.32E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578406(CHEMBL4869807)
Affinity DataKi:  3.32E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558637(US11365202, Compound 2)
Affinity DataKi:  3.49E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578405(CHEMBL4856045)
Affinity DataKi:  3.49E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558640(US11365202, Compound 5)
Affinity DataKi:  4.54E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578408(CHEMBL4857754)
Affinity DataKi:  4.54E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558643(US11365202, Compound 3b)
Affinity DataKi:  6.91E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578420(CHEMBL4853187)
Affinity DataKi:  6.91E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCysteine proteinase falcipain 2a(Plasmodium falciparum)
India

Curated by ChEMBL
LigandPNGBDBM50578418(CHEMBL4871791)
Affinity DataKi:  9.92E+3nMAssay Description:Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeme ligase(Plasmodium falciparum (isolate 3D7))
Council of Scientific and Industrial Research

US Patent
LigandPNGBDBM558643(US11365202, Compound 3b)
Affinity DataKi:  9.92E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160076(US10047092, 17 | US10053463, 17 | US9040534, 17)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM242031(US9415055, 2,3-Dichloro-N-[2-(4,4-difluoro-piperid...)
Affinity DataIC50:  0.330nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM242031(US9415055, 2,3-Dichloro-N-[2-(4,4-difluoro-piperid...)
Affinity DataIC50:  0.330nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160077(US10047092, 18 | US10053463, 18 | US9040534, 18)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254080((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM48901(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160087(US10047092, 28 | US10053463, 28 | US9040534, 28)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160089(US10047092, 30 | US10053463, 30 | US9040534, 30)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160075(US10047092, 16 | US9040534, 16)
Affinity DataIC50:  0.700nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM173694(US9102591, 2,3-dichloro-N-[2-(6-cyclopropyl-3-pyri...)
Affinity DataIC50:  0.790nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM173694(US9102591, 2,3-dichloro-N-[2-(6-cyclopropyl-3-pyri...)
Affinity DataIC50:  0.790nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium mobilization monitored for 5 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254077(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM160072(US10047092, 13 | US9040534, 13)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human P2X7 receptor expressed in 1321N1 cells assessed as inhibition of Bz-ATP-induced Ca2+ flux after 30 mins by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254325(CHEMBL469302 | N7-(4-tert-butylphenyl)-N2-(2,6-dic...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254080((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research And Development

Curated by ChEMBL
LigandPNGBDBM50254419(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM241720(US9409917, 17 | US9409917, 18)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM241720(US9409917, 17 | US9409917, 18)
Affinity DataIC50:  1.30nMAssay Description:Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced calcium mobilization incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50352039(CHEMBL1823817)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity against human P2X7 receptor assessed as inhibition of IL-1beta production by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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