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Found 62 with Last Name = 'bolton' and Initial = 'jl'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50250422((+)-N-methyl-laurotetanine | CHEMBL464099 | N-meth...)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50259677(CHEMBL481839 | escholtzine)
Affinity DataKi:  6.00E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19443(2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy...)
Affinity DataIC50:  7.80nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19443(2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy...)
Affinity DataIC50:  9.60nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19446(2-phenyl-3-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1...)
Affinity DataIC50:  10.9nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19446(2-phenyl-3-{4-[2-(piperidin-1-yl)ethoxy]phenoxy}-1...)
Affinity DataIC50:  16.3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19444(2-(4-fluorophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]...)
Affinity DataIC50:  17.2nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19448(2-(4-aminophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]p...)
Affinity DataIC50:  19.3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  20.6nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  21.5nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19445(2-(4-bromophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]p...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19447(2-(4-methanesulfonylphenyl)-3-{4-[2-(piperidin-1-y...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19444(2-(4-fluorophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]...)
Affinity DataIC50:  27.9nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19450(2-{4-[(2-chloroethyl)amino]phenyl}-3-{4-[2-(piperi...)
Affinity DataIC50:  35.6nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19448(2-(4-aminophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]p...)
Affinity DataIC50:  48.6nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19442(2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)p...)
Affinity DataIC50:  66.3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19445(2-(4-bromophenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]p...)
Affinity DataIC50:  66.7nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataIC50:  557nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19449(2-chloro-N-[4-(6-hydroxy-3-{4-[2-(piperidin-1-yl)e...)
Affinity DataIC50:  666nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19450(2-{4-[(2-chloroethyl)amino]phenyl}-3-{4-[2-(piperi...)
Affinity DataIC50: >1.60E+3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19447(2-(4-methanesulfonylphenyl)-3-{4-[2-(piperidin-1-y...)
Affinity DataIC50:  1.80E+3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19449(2-chloro-N-[4-(6-hydroxy-3-{4-[2-(piperidin-1-yl)e...)
Affinity DataIC50:  2.36E+3nMpH: 7.5 T: 2°CAssay Description:Arzoxifene and its analogues were assayed in the standard ER competitive radioligand binding assay, using full length human recombinant ER-alpha and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50259677(CHEMBL481839 | escholtzine)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50259746((4-Hydroxyphenyl)ethyl trans-ferulate | CHEMBL4812...)
Affinity DataIC50:  4.76E+4nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50217942(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chr...)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50377936(CALIFORNIDINE)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50377937(PROTOPINE)
Affinity DataIC50: >8.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50071370((3R,8S)-falcarindiol | (3R,8S,)-heptadeca-1,9-dien...)
Affinity DataIC50:  1.18E+5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50250299((9Z,11S,16R)-dihydroxyoctadeca-9,17-dien-12,14-diy...)
Affinity DataIC50:  1.18E+5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50241315((Z)-3-butylideneisobenzofuran-1(3H)-one | CHEMBL24...)
Affinity DataIC50:  1.27E+5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50259759((S)-8-hydroxy-1-methoxy-, Z-9-heptadecene-4,6-diyn...)
Affinity DataIC50: >1.50E+5nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataEC50:  50nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0300nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.0300nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  80nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataEC50:  5nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50106635((+/-)-2,3-bis(4-hydroxyphenyl)propanenitrile | 2,3...)
Affinity DataEC50:  20nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataEC50:  5nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19459(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataEC50:  2.40nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50398935(PROPYLPYRAZOLETRIOL)
Affinity DataEC50:  1nMAssay Description:Estrogenic activity at ERalpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-nitrophenol as substrate treate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50240972(5,7-Dihydroxy-2-(4-hydroxy-phenyl)-8-(3-methyl-but...)
Affinity DataEC50:  3.5nMAssay Description:Estrogenic activity at ERbeta (unknown origin) expressed in human MDA-MB-231/beta41 cells after 18 hrs by renilla luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  0.200nMAssay Description:Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol pho...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM50252521(CHEMBL492828 | isoxanthohumol)
Affinity DataEC50:  1.40E+3nMAssay Description:Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM19460((2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-8-(3-methyl...)
Affinity DataEC50:  7nMAssay Description:Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM58016(2-(4-hydroxyphenyl)-6-(3-methylbut-2-enyl)-5,7-bis...)
Affinity DataEC50:  400nMAssay Description:Estrogenic activity at estrogen receptor alpha in human Ishikawa cells assessed as induction of alkaline phosphatase activity using p-Nitrophenol pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM78940(METHIOTHEPIN | MLS000859918 | Methiothepin mesylat...)
Affinity DataEC50:  0.600nMAssay Description:Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM30704((phenylmethyl) N-[[(6aR,9S,10aR)-4,7-dimethyl-6,6a...)
Affinity DataEC50:  7.5nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50259677(CHEMBL481839 | escholtzine)
Affinity DataEC50:  1.10E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50250422((+)-N-methyl-laurotetanine | CHEMBL464099 | N-meth...)
Affinity DataEC50:  160nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Tom'S Of Maine

Curated by ChEMBL
LigandPNGBDBM50259678(CHEMBL480663 | caryachine)
Affinity DataEC50:  9.00E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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