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Found 90 with Last Name = 'butler' and Initial = 'de'
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  0.280nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50334150(1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  0.400nMAssay Description:Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  2.80nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225510(CHEMBL156395)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  17nMAssay Description:Affinity for displacement of [3H]-WB-4101 labeled Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor in rat brain using [3H]- QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  20nMAssay Description:Binding affinity against serotonin-2 receptor in rat brain using [3H]spiroperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  20nMAssay Description:The compound was tested for inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  30nMAssay Description:Binding affinity against dopamine receptor in rat striatal membrane using [3H]haloperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  33nMAssay Description:Binding affinity against serotonin-2 receptor in rat brain using [3H]spiroperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  38nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  40nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  40nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat brain using [3H]- WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  48nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  54nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in rat brain using [3H]- WB-4101More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  54nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  60nMAssay Description:Ability to inhibit [3H]haloperidol binding to dopamine receptor in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  61nMAssay Description:Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM78433(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Affinity DataIC50:  80nMAssay Description:The compound was tested for adenylate cyclase activity in rat corpus striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50: >100nMAssay Description:The compound was tested for inhibition of [3H]QNB binding to Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50225369(CHEMBL295712)
Affinity DataIC50: >1.00E+3nMAssay Description:The compound was tested for inhibition of rabbit plasma renin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019916(2,2-Dichloro-N-[(3-chloro-phenyl)-(5-hydroxy-1,3-d...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019909(CHEMBL3144632 | N-[(3-Chloro-phenyl)-(5-hydroxy-1,...)
Affinity DataIC50: >1.00E+3nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Affinity DataIC50:  1.30E+3nMAssay Description:Affinity for displacement of [3H]-clonidine labeled Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  6.00E+3nMAssay Description:Binding affinity against alpha-2 adrenergic receptor in rat brain using [3H]- clonidineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  6.00E+3nMAssay Description:The compound was tested for inhibition of [3H]WB-4101 binding to alpha-1 adrenergic receptor of rat frontal cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50:  6.60E+3nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor in rat brain using [3H]- QNBMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50:  8.70E+3nMAssay Description:Binding affinity against serotonin-1 receptor in rat brain using [3H]5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019908(4-[(3-Chloro-phenyl)-imino-methyl]-2-ethyl-5-methy...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019910(4-(Imino-phenyl-methyl)-2,5-dimethyl-2H-pyrazol-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019911(2-Ethyl-4-(imino-phenyl-methyl)-5-methyl-2H-pyrazo...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019912(4-[(4-Fluoro-phenyl)-imino-methyl]-2,5-dimethyl-2H...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019913(4-[(3-Chloro-phenyl)-imino-methyl]-2,5-dimethyl-2H...)
Affinity DataIC50: >1.00E+4nMAssay Description:Affinity for displacement of [3H]-clonidine labeled Dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019914(4-[(3-Bromo-phenyl)-imino-methyl]-2,5-dimethyl-2H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019915(4-[(3-Chloro-phenyl)-imino-methyl]-2-isopropyl-5-m...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019913(4-[(3-Chloro-phenyl)-imino-methyl]-2,5-dimethyl-2H...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019918(4-[(3-Chloro-phenyl)-imino-methyl]-5-methyl-2-prop...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019917(4-[Imino-(4-trifluoromethyl-phenyl)-methyl]-2,5-di...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019920(4-[(3-Fluoro-phenyl)-imino-methyl]-2,5-dimethyl-2H...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50019919(CHEMBL3144848 | N-[(3-Chloro-phenyl)-(5-hydroxy-1,...)
Affinity DataIC50: >1.00E+4nMAssay Description:In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50019457(2-Diethylamino-N-[4-(2-fluoro-benzoyl)-2,5-dimethy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against the beta-2 adrenergic receptor using [3H]- DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50019458(CHEMBL45063 | N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-2 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-2 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-1 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50019458(CHEMBL45063 | N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Binding affinity against beta-2 adrenergic receptor in rat brain using [3H]-DHAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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