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Found 241 with Last Name = 'cowan' and Initial = 'c'
TargetMu-type opioid receptor(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataKi:  6nMAssay Description:Binding affinity to human mu opioid receptor by radio-ligand binding assayMore data for this Ligand-Target Pair
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataKi:  398nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataKi:  1.59E+3nMAssay Description:Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataIC50:  4.60nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470654(CHEMBL141019)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50003392(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  31nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50029659(2-Methyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylsul...)
Affinity DataIC50:  96nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50003391(2-Methyl-4-{2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...)
Affinity DataIC50:  270nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470658(CHEMBL142409)
Affinity DataIC50:  350nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50003406(2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataIC50:  370nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422411(CHEMBL154419)
Affinity DataIC50:  794nMAssay Description:Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422411(CHEMBL154419)
Affinity DataIC50:  1.00E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50470655(CHEMBL341724)
Affinity DataIC50:  1.50E+3nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422410(CHEMBL348501)
Affinity DataIC50:  2.00E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470656(CHEMBL358791)
Affinity DataIC50:  4.70E+3nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422409(CHEMBL347582)
Affinity DataIC50:  5.01E+3nMAssay Description:Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422410(CHEMBL348501)
Affinity DataIC50:  5.01E+3nMAssay Description:Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470659(CHEMBL358044)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50470657(CHEMBL142300)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of ratsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422409(CHEMBL347582)
Affinity DataIC50:  1.58E+4nMAssay Description:Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50:  1.65E+4nMAssay Description:Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human Nav 1.5 tonic ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493818(Oliceridine | TRV-130 | US11124523, Comparative Co...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Trevena

Curated by ChEMBL
LigandPNGBDBM50493811(CHEMBL2443278)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human Cav 1.2 ion channel expressed in HEK293 cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataEC50:  4nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002596(CHEMBL424866)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002597(CHEMBL377028)
Affinity DataEC50:  631nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422411(CHEMBL154419)
Affinity DataEC50:  79nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataEC50:  3.98E+3nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002598(CHEMBL152535)
Affinity DataEC50:  25nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002596(CHEMBL424866)
Affinity DataEC50:  5.01E+3nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002599(CHEMBL205224)
Affinity DataEC50:  50nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002601(CHEMBL383511)
Affinity DataEC50:  1.59E+3nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM25392(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Affinity DataEC50:  1nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002601(CHEMBL383511)
Affinity DataEC50:  32nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002597(CHEMBL377028)
Affinity DataEC50:  0.25nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002595(Solabegron)
Affinity DataEC50:  1.26E+3nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002602(CHEMBL205389)
Affinity DataEC50:  63nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002602(CHEMBL205389)
Affinity DataEC50:  3.98E+3nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50422411(CHEMBL154419)
Affinity DataEC50:  16nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002605(CHEMBL206002)
Affinity DataEC50:  2.51E+3nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002606(CHEMBL204827)
Affinity DataEC50:  1.60nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002608(CHEMBL207943)
Affinity DataEC50: <1.00E+4nMAssay Description:Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-3 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002605(CHEMBL206002)
Affinity DataEC50:  0.200nMAssay Description:Activity at human beta-3 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002606(CHEMBL204827)
Affinity DataEC50:  794nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50002598(CHEMBL152535)
Affinity DataEC50: <794nMAssay Description:Activity at human beta-1 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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