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Found 298 with Last Name = 'crews' and Initial = 'p'
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataKi:  700nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataKi:  800nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572159(CHEMBL1489870)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataKi:  900nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572160(CHEMBL1452107)
Affinity DataKi:  2.50E+3nMAssay Description:Competitive inhibition of human 15-LOX-2 assessed as equilibrium dissociation constant from catalytic site by measuring 15-HpETE by Dixon plots and D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50221405(CHEMBL391079 | dysidenin)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of human 15-hLO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50221405(CHEMBL391079 | dysidenin)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50221404(CHEMBL392270 | neodysidenin)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50221404(CHEMBL392270 | neodysidenin)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human 15-hLO1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50295172(4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methy...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM17446((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Affinity DataIC50:  1nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM227589(Radicicol)
Affinity DataIC50:  19nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50113436(CHEMBL32838 | fumagillin)
Affinity DataIC50:  30nMAssay Description:Inhibition of methionine aminopeptidase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Colorado Mesa University

Curated by ChEMBL
LigandPNGBDBM50267199(CHEMBL4079583)
Affinity DataIC50:  100nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50150780(4-[(2R)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]...)
Affinity DataIC50:  110nMAssay Description:Inhibitory effect on human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  110nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50158387(4-[(3-carboxy-4-hydroxy-1-naphthyl)(oxo)acetyl]-1-...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM22372(4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbut...)
Affinity DataIC50:  180nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetolactate synthase catalytic subunit, mitochondrial(Saccharomyces cerevisiae)
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Saccharomyces cerevisiae acetolactate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50267200(CHEMBL4077166)
Affinity DataIC50:  200nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50221402(CHEMBL238624 | NSC-172033)
Affinity DataIC50:  210nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50242010((+)-(5S,8S,9R,10S)-20-methoxypuupehenone | CHEMBL4...)
Affinity DataIC50:  260nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50242017((+)-(5S,8S,10S)-20-methoxypuupehenol | (+)-(5S,8S,...)
Affinity DataIC50:  280nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50240936(2-[(2E,6E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohe...)
Affinity DataIC50:  300nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM68853(1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidaz...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50267194(CHEMBL4089242)
Affinity DataIC50:  380nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50150794(CHEMBL186752 | N-[2-(3-Bromo-4-hydroxy-phenyl)-eth...)
Affinity DataIC50:  400nMAssay Description:Inhibitory effect on human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Colorado Mesa University

Curated by ChEMBL
LigandPNGBDBM17847(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50295174(Bengamide A | CHEMBL256279)
Affinity DataIC50:  400nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50267193(CHEMBL4078211)
Affinity DataIC50:  400nMAssay Description:Inhibition of human MetAP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50135851(2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...)
Affinity DataIC50:  410nMAssay Description:Inhibitory effect on human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50240936(2-[(2E,6E)-3,7-Dimethyl-9-(2,6,6-trimethyl-cyclohe...)
Affinity DataIC50:  450nMAssay Description:Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50206259(CHEMBL230058 | hydrohalisulfate 1)
Affinity DataIC50:  500nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50320449((-)-ZILEUTON | CHEMBL1164975)
Affinity DataIC50:  500nMAssay Description:Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572161(CHEMBL1520238)
Affinity DataIC50:  530nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50065997(5-[4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethyl-(2R,...)
Affinity DataIC50:  580nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50214969(1,3,6-Trihydroxy-7-methoxy-2,8-bis-(3-methyl-but-2...)
Affinity DataIC50:  580nMAssay Description:Inhibition of human 12-hLOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50240865((4aS,6aS,12aR,12bS)-10-Hydroxy-4,4,6a,12b-tetramet...)
Affinity DataIC50:  680nMAssay Description:Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50150785(2,3,4,5-Tetrabromo-6-(2,4-dibromo-phenoxy)-phenol ...)
Affinity DataIC50:  700nMAssay Description:Inhibitory effect on human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Colorado Mesa University

Curated by ChEMBL
LigandPNGBDBM50295174(Bengamide A | CHEMBL256279)
Affinity DataIC50:  700nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Colorado Mesa University

Curated by ChEMBL
LigandPNGBDBM50267193(CHEMBL4078211)
Affinity DataIC50:  700nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50240865((4aS,6aS,12aR,12bS)-10-Hydroxy-4,4,6a,12b-tetramet...)
Affinity DataIC50:  760nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50269763((+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol | C...)
Affinity DataIC50:  780nMAssay Description:Inhibition of His-tagged human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50135851(2,3,4,5-tetrabromo-6-(3,5-dibromo-2-hydroxy-phenox...)
Affinity DataIC50:  790nMAssay Description:Inhibitory effect on human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50150791(3,6,8-Tribromo-dibenzo[1,4]dioxin-1-ol | CHEMBL185...)
Affinity DataIC50:  800nMAssay Description:Inhibitory effect on human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50269748(21-chloro-puupehenone | CHEMBL465616 | chloropuupe...)
Affinity DataIC50:  830nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
University Of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50572162(CHEMBL1352020)
Affinity DataIC50:  870nMAssay Description:Inhibition of human 15-LOX-2 assessed as enzymatic rate using arachidonic acid as substrate by UV/Vis spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50206257(CHEMBL387584 | CHEMBL450482 | halisulfate 1 | sodi...)
Affinity DataIC50:  900nMAssay Description:Inhibition of His-tagged human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50150784(3,4,6,8-Tetrabromo-dibenzo[1,4]dioxin-1-ol | CHEMB...)
Affinity DataIC50:  900nMAssay Description:Inhibitory effect on human reticulocyte 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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