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Found 837 with Last Name = 'dodd' and Initial = 'r'
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.00480nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390197(CHEMBL1917286)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390205(CHEMBL2069863)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390207(CHEMBL2069865)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390206(CHEMBL2069864)
Affinity DataKi:  0.152nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.160nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324097(CHEMBL1214831 | N-(Benzofuran-2-ylmethyl)-N'-(4'-e...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324100(CHEMBL1214830 | N-((Benzofuran-2-yl)methyl)-N'-(4'...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390204(CHEMBL2069862)
Affinity DataKi:  0.194nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  0.490nMAssay Description:Inhibitory activity of the compound against Human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390203(CHEMBL2069861)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374598(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50068454(1-[2-(3-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098580(Benzofuran-2-carboxylic acid {3-methyl-1-[2-oxo-3-...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324086(CHEMBL1214893 | N-(Benzofuran-2-ylmethyl)-N'-(4'-(...)
Affinity DataKi:  1.61nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098584(CHEMBL31947 | {1-[4-(2-Benzyloxycarbonylamino-4-me...)
Affinity DataKi:  2nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity of the compound against Human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098579(CHEMBL29483 | {1-[3-(2-Benzyloxycarbonylamino-4-me...)
Affinity DataKi:  2.30nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445231(CHEMBL3102950)
Affinity DataKi:  2.30nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098575(CHEMBL281086 | {1-[4-(2-Benzyloxycarbonylamino-4-m...)
Affinity DataKi:  2.60nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity of the compound against Human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50338990(1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piper...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50338990(1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piper...)
Affinity DataKi:  4.60nMAssay Description:Binding affinity to sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098581(5-(2-Morpholin-4-yl-ethoxy)-benzofuran-2-carboxyli...)
Affinity DataKi:  4.70nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  4.80nMAssay Description:Inhibitory activity of the compound against Rat cathepsin KMore data for this Ligand-Target Pair
LigandPNGBDBM50445230(CHEMBL3102951)
Affinity DataKi:  5.5nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401369(CHEMBL2205822)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50125096(1,4-Dibenzyl-piperazine | 1,4-Dibenzyl-piperazine,...)
Affinity DataKi:  5.81nMAssay Description:Binding affinity to sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390200(CHEMBL2069964)
Affinity DataKi:  6.45nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401366(CHEMBL2205831)
Affinity DataKi:  6.70nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19782((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2...)
Affinity DataKi:  7.5nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445229(CHEMBL3102953)
Affinity DataKi:  7.60nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445227(CHEMBL3102955)
Affinity DataKi:  10nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401370(CHEMBL2205821)
Affinity DataKi:  10nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324085(CHEMBL1214892 | N-(Benzofuran-2-ylmethyl)-N'-(4'-p...)
Affinity DataKi:  10.3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50445228(CHEMBL3102954)
Affinity DataKi:  12nMAssay Description:Competitive inhibition of rat recombinant 6xHis-tagged DYRK1A catalytic domain (1 to 502) expressed in Escherichia coli BL21 (DE3) using ATP as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098576(5-(2-MORPHOLIN-4-YLETHOXY)BENZOFURAN-2-CARBOXYLIC ...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity of the compound against Human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401368(CHEMBL2205813)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401376(CHEMBL2205812)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098578(CHEMBL286034 | {1-[4-(2-Benzyloxycarbonylamino-4-m...)
Affinity DataKi:  15nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401371(CHEMBL2205820)
Affinity DataKi:  15nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098575(CHEMBL281086 | {1-[4-(2-Benzyloxycarbonylamino-4-m...)
Affinity DataKi:  16nMAssay Description:Inhibitory activity of the compound against Human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401372(CHEMBL2205819)
Affinity DataKi:  17nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390199(CHEMBL2069963)
Affinity DataKi:  19.3nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM19782((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity of the compound against Human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390202(CHEMBL2069966)
Affinity DataKi:  20.8nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50066650(1,3-BIS[[N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL]AMIN...)
Affinity DataKi:  22nMAssay Description:Inhibition of Human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401377(CHEMBL2205835)
Affinity DataKi:  26nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098584(CHEMBL31947 | {1-[4-(2-Benzyloxycarbonylamino-4-me...)
Affinity DataKi:  26nMAssay Description:Inhibitory activity of the compound against Human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50401374(CHEMBL2205815)
Affinity DataKi:  26nMAssay Description:Displacement of [3H](+)-pentazocine from rat brain sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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