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Found 2248 with Last Name = 'eddy' and Initial = 'p'
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069218((2R,3R)-2,N*1*-Dihydroxy-3-isobutyl-N*4*-[(S)-2-(4...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataKi:  0.790nMAssay Description:Binding affinity at human prostaglandin EP4 receptorMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069218((2R,3R)-2,N*1*-Dihydroxy-3-isobutyl-N*4*-[(S)-2-(4...)
Affinity DataKi: <1nMAssay Description:Binding affinity was evaluated against matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069214((2R,3R)-N*4*-((S)-5-Amino-1-methylcarbamoyl-pentyl...)
Affinity DataKi: <1nMAssay Description:Binding affinity was evaluated against matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069224((2R,3R)-2,N*1*-Dihydroxy-N*4*-{(S)-1-[((R)-hydroxy...)
Affinity DataKi:  1nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069213((2R,3R)-N*4*-((S)-5-Amino-1-phenethylcarbamoyl-pen...)
Affinity DataKi:  1nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069221((2R,3R)-N*4*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataKi: <1nMAssay Description:Binding affinity was evaluated against matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069228((2R,3R)-2,N*1*-Dihydroxy-N*4*-[(S)-2-(4-methoxy-ph...)
Affinity DataKi: <1nMAssay Description:Binding affinity was evaluated against matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069220((2R,3R)-2,N*1*-Dihydroxy-N*4*-[(S)-2-(4-methoxy-ph...)
Affinity DataKi:  2nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069228((2R,3R)-2,N*1*-Dihydroxy-N*4*-[(S)-2-(4-methoxy-ph...)
Affinity DataKi:  2nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50200120(CHEMBL260091 | CHIR-090 | US10875832, Compound ChI...)
Affinity DataKi:  2nMAssay Description:Inhibition of Escherichia coli LpxCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069226(CHEMBL265216 | {(S)-4-[(R)-2-((R)-1-Hydroxy-1-hydr...)
Affinity DataKi:  2nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069217((2R,3R)-2,N*1*-Dihydroxy-N*4*-((S)-4-dimethylamino...)
Affinity DataKi:  2nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314147(CHEMBL1094014 | trans-4-(4-(1-benzyl-5-(dimethylam...)
Affinity DataKi:  3nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069228((2R,3R)-2,N*1*-Dihydroxy-N*4*-[(S)-2-(4-methoxy-ph...)
Affinity DataKi:  3nMAssay Description:Binding affinity against human matrix metalloproteinase-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...)
Affinity DataKi:  4nMAssay Description:Inhibition of TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069216((2R,3R)-2,N*1*-Dihydroxy-2-methyl-N*4*-{(S)-1-meth...)
Affinity DataKi:  4nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM35847((15S)-prostaglandin E2 | (5Z,11alpha,13E,15S)-11,1...)
Affinity DataKi:  4.90nMAssay Description:Binding affinity at human prostaglandin EP2 receptorMore data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069219((2R,3R)-N*4*-((S)-4-Amino-1-methylcarbamoyl-butyl)...)
Affinity DataKi:  5nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069223((2R,3R)-3-Benzyl-2,N*1*-dihydroxy-N*4*-[(S)-2-(4-m...)
Affinity DataKi:  5nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182403((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...)
Affinity DataKi:  5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314147(CHEMBL1094014 | trans-4-(4-(1-benzyl-5-(dimethylam...)
Affinity DataKi:  5nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185909(2-(3-((1-(3-(2-chlorophenoxy)benzyl)piperidin-4-yl...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314147(CHEMBL1094014 | trans-4-(4-(1-benzyl-5-(dimethylam...)
Affinity DataKi:  6nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...)
Affinity DataKi:  7nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069224((2R,3R)-2,N*1*-Dihydroxy-N*4*-{(S)-1-[((R)-hydroxy...)
Affinity DataKi:  7nMAssay Description:Binding affinity against human matrix metalloproteinase-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM50102258((S)-2-[3-((S)-3-Carboxy-1-carboxy-propyl)-ureido]-...)
Affinity DataKi:  8nMAssay Description:Binding affinity PSMA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185912(2-(4-{1-[3-(2-chloro-phenoxy)-benzyl]-piperidin-4-...)
Affinity DataKi:  9nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314148(CHEMBL1089007 | trans-4-(4-(3-(tetrahydro-2H-pyran...)
Affinity DataKi:  9nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50182403((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...)
Affinity DataKi:  10nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185908(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50224575((S)-4-(2-(2-(4-(3-bromophenyl)-3-hydroxybutyl)-5-o...)
Affinity DataKi:  13nMAssay Description:Binding affinity at human prostaglandin EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50224577(4-(2-(2-(4-(3-bromophenyl)-3-hydroxybutyl)-5-oxopy...)
Affinity DataKi:  13nMAssay Description:Binding affinity at human prostaglandin EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069221((2R,3R)-N*4*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataKi:  13nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069226(CHEMBL265216 | {(S)-4-[(R)-2-((R)-1-Hydroxy-1-hydr...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human matrix metalloproteinase-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069218((2R,3R)-2,N*1*-Dihydroxy-3-isobutyl-N*4*-[(S)-2-(4...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human matrix metalloproteinase-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069221((2R,3R)-N*4*-((S)-2,2-Dimethyl-1-methylcarbamoyl-p...)
Affinity DataKi:  13nMAssay Description:Binding affinity against human matrix metalloproteinase-3.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185910(1-ethyl-4-phenyl-piperidine-4-carboxylic acid {1-[...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069214((2R,3R)-N*4*-((S)-5-Amino-1-methylcarbamoyl-pentyl...)
Affinity DataKi:  15nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069226(CHEMBL265216 | {(S)-4-[(R)-2-((R)-1-Hydroxy-1-hydr...)
Affinity DataKi:  16nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314148(CHEMBL1089007 | trans-4-(4-(3-(tetrahydro-2H-pyran...)
Affinity DataKi:  16nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Portola Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193846(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Portola Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50193867(1-({4-[4-chloro-2-(5-chloro-pyridin-2-ylcarbamoyl)...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]dofetilide from human ERG potassium channel expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50314148(CHEMBL1089007 | trans-4-(4-(3-(tetrahydro-2H-pyran...)
Affinity DataKi:  17nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069219((2R,3R)-N*4*-((S)-4-Amino-1-methylcarbamoyl-butyl)...)
Affinity DataKi:  18nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Emd-Serono Research Institute

Curated by ChEMBL
LigandPNGBDBM50224572(4-(2-(2-(4-(3-chlorophenyl)-3-hydroxybutyl)-5-oxop...)
Affinity DataKi:  18nMAssay Description:Binding affinity at human prostaglandin EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50074364(CHEMBL350356 | N*2*-(2-Bromo-4-isopropyl-phenyl)-N...)
Affinity DataKi:  18nMAssay Description:Inhibition of [125I]-ovine-CRF binding to corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50182403((2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-...)
Affinity DataKi:  21nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50069217((2R,3R)-2,N*1*-Dihydroxy-N*4*-((S)-4-dimethylamino...)
Affinity DataKi:  22nMAssay Description:Binding affinity was evaluated against matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
Millennium Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50185906(1-[3-(2-chlorophenoxy)benzyl]-4-{[(1-ethyl-4-pheny...)
Affinity DataKi:  23nMAssay Description:Displacement of [125I]I309 from human CCR8 expressed in L1.2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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