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Found 43 with Last Name = 'gadaleta' and Initial = 'rm'
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50354850(BUDESONIDE | US10869929, Compound Budesonide | US1...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50:  140nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  7.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50:  600nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50:  400nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  3.30E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  4.15E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50127222(CHEMBL38508 | GW-0742 | {4-[2-(3-Fluoro-4-trifluor...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-gammaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50085048((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at human PPAR-gammaMore data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50030477(CHEBI:77317 | CHEMBL458767 | SR-12813)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human PXRMore data for this Ligand-Target Pair
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM31892(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at human RXR-alphaMore data for this Ligand-Target Pair
TargetVitamin D3 receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  0.100nMAssay Description:Agonist activity at human VDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetEstrogen receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human ERMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human ERMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at human PRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human TRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human GRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair