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Found 111 with Last Name = 'gambari' and Initial = 'r'
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50335390(CHEMBL1651630 | N-Hexoxypentyl-1-deoxynojirimycin)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524479(CHEMBL4459011)
Affinity DataIC50:  1nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50299749((2R,3R,4R,5S)-1-[5-(Adamantan-1-ylmethoxy)-pentyl]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM18358((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524480(CHEMBL4559665)
Affinity DataIC50:  4nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089962(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-be...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089960(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089961(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1-...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089967(5-{4-[Bis-(2-chloro-ethyl)-amino]-benzoylamino}-1H...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089969(5-[Bis-(2-chloro-ethyl)-amino]-benzofuran-2-carbox...)
Affinity DataIC50:  15nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089978(5-[Bis-(2-chloro-ethyl)-amino]-1H-indole-2-carboxy...)
Affinity DataIC50:  20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50089971(5-[Bis-(2-chloro-ethyl)-amino]-1-methyl-1H-indole-...)
Affinity DataIC50:  20nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50335387(CHEMBL1651633 | N-Nonoxypentyl-1-deoxynojirimycin)
Affinity DataIC50:  34nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50156357(2-Hydroxymethyl-1-nonyl-piperidine-3,4,5-triol | C...)
Affinity DataIC50:  35nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524486(CHEMBL4577406)
Affinity DataIC50:  44nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524485(CHEMBL4435506)
Affinity DataIC50:  65nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524481(CHEMBL4459494)
Affinity DataIC50:  137nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50055659(2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-meth...)
Affinity DataIC50:  200nMAssay Description:Tested for 50% inhibition of generation of Human Ha-ras polymerase chain reaction(PCR) productsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524484(CHEMBL187262)
Affinity DataIC50:  260nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475850(CHEMBL378632)
Affinity DataIC50:  980nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475848(CHEMBL380060)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475851(CHEMBL212515)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475847(CHEMBL210239)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50035218(CHEMBL61 | PODOFILOX | Podophyllinic acid lactone ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475852(CHEMBL209011)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475853(CHEMBL379867)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50475849(CHEMBL212734)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of tubulin polymerization in bovine brain by tubulin assembly assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331545(2H-furo[2,3-h]chromen-2-one | CHEMBL53569 | Furo[2...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331544(7H-furo[3,2-g]chromen-7-one | CHEMBL164660 | Furo[...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524482(CHEMBL4460711)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331548(4-((7-hydroxy-4-oxo-1,2,3,4-tetrahydrocyclopenta[c...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50335390(CHEMBL1651630 | N-Hexoxypentyl-1-deoxynojirimycin)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM18358((2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50243651(CHEMBL4061367)
Affinity DataIC50:  7.70E+3nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50072339(Benzodiazepine-Distamycin Hybrid | CHEMBL102341)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of Ha-ras polymerase-chain reaction productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331546(2-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)benzenes...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331542(3-(benzo[d][1,3]dioxol-5-yl)-5-phenyl-7H-furo[3,2-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331543(3-(3-fluoro-4-methoxyphenyl)-5-phenyl-7H-furo[3,2-...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331547(CHEMBL210287 | bromopyrogallol red)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-lysosomal glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524483(CHEMBL4435540)
Affinity DataIC50:  3.67E+4nMAssay Description:Inhibition of NLGase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331541(2-(2-methoxyethylamino)-6-methyl-3-(3,4,5-trimetho...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50146462((2E)-3-(2-hydroxyphenyl)-2-propenoic acid | (2E)-3...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50331540(8-(4-Methoxy-benzoyl)-4-methyl-9-phenyl-furo[2,3-h...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50243651(CHEMBL4061367)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM18355((2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-...)
Affinity DataIC50:  1.18E+5nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of Napoli Federico Ii

Curated by ChEMBL
LigandPNGBDBM50524482(CHEMBL4460711)
Affinity DataIC50:  1.36E+5nMAssay Description:Inhibition of GCase in human SH-SY5Y cells using MUG-Gluc as fluorogenic substrate preincubated for 30 mins followed by substrate addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase HRas(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50055659(2N-(3,3-aminoiminopropyl)-4-[4-(4-formamido-1-meth...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of Ha-ras polymerase-chain reaction productMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear factor NF-kappa-B p105 subunit(Homo sapiens (Human))
Biopharmanet

Curated by ChEMBL
LigandPNGBDBM50022178(4-Methyl-7-hydroxycoumarin | 4-methylumbelliferone...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition of NF-KB p50 subunit/DNA interaction after 20 mins by EMSAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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