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Found 94 with Last Name = 'gensmantel' and Initial = 'np'
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36395(5-Fluoro-2-thiophen-2-yl-1,2-dihydroquinazolin-4-a...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  15nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
LigandPNGBDBM50040461((S)-5-(4-Benzyl-phenylsulfanyl)-4-((S)-7-phenyl-he...)
Affinity DataIC50:  15nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040458((S)-4-((S)-(E)-Dec-3-enoylamino)-5-(naphthalen-2-y...)
Affinity DataIC50:  16nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040461((S)-5-(4-Benzyl-phenylsulfanyl)-4-((S)-7-phenyl-he...)
Affinity DataIC50:  21nMAssay Description:Compound was tested for in vitro activity against s-phospholipase A2 (s-PLA2) isolated from human plateletsMore data for this Ligand-Target Pair
LigandPNGBDBM50040464((S)-3-((S)-(E)-Dec-3-enoylamino)-4-(naphthalen-2-y...)
Affinity DataIC50:  23nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  23nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040455((S)-4-(4-Benzyl-phenylsulfanyl)-3-((S)-(E)-dec-3-e...)
Affinity DataIC50:  30nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Fisons

Curated by ChEMBL
LigandPNGBDBM50004502(CHEMBL101972 | Phosphoric acid 2-hexadecanoylamino...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by monomeric substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040461((S)-5-(4-Benzyl-phenylsulfanyl)-4-((S)-7-phenyl-he...)
Affinity DataIC50:  30nMAssay Description:Compound was tested for in vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Fisons

Curated by ChEMBL
LigandPNGBDBM50004495(CHEMBL101015 | Hexadecanoic acid 3-[hydroxy-(2-hyd...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by monomeric substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36396(CD24894148 | N-[2-(4-Amino-5,8-difluoro-1,2-dihydr...)
Affinity DataIC50:  31nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091817(4-Methyl-6-propyl-pyridin-2-ylamine | 4-Methyl-6-p...)
Affinity DataIC50:  34nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  35nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  40nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  40nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040466((S)-4-(4-Benzyl-phenylsulfanyl)-3-((S)-7-phenyl-he...)
Affinity DataIC50:  65nMAssay Description:Compound was tested for in vitro activity against s-phospholipase A2 (s-PLA2) isolated from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148167(4-(4-(4-methoxypyridin-2-ylamino)piperidine-1-carb...)
Affinity DataIC50:  74nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36401((2S)-2-Methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  80nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148164(4-(4-Methoxy-pyridin-2-ylamino)-piperidine-1-carbo...)
Affinity DataIC50:  90nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040465((S)-3-((S)-(E)-Dec-3-enoylamino)-4-phenylsulfanyl-...)
Affinity DataIC50:  95nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36399(CID10221335 | N-[2-(6-Amino-4-methylpyridin-2-yl)e...)
Affinity DataIC50:  120nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  120nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040455((S)-4-(4-Benzyl-phenylsulfanyl)-3-((S)-(E)-dec-3-e...)
Affinity DataIC50:  120nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36397((4-Amino-5-fluorospiro[1H-quinazoline-2,4'-pip...)
Affinity DataIC50:  130nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  160nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040456((R)-3-((S)-Hexadecanoylamino)-5-methyl-hexanoic ac...)
Affinity DataIC50:  190nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040463((S)-4-((S)-Hexadecanoylamino)-6-methyl-heptanoic a...)
Affinity DataIC50:  200nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36402((3R)-3-Propyl-2,3-dihydrothieno[2,3-f][1,4]oxazepi...)
Affinity DataIC50:  200nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Fisons

Curated by ChEMBL
LigandPNGBDBM50004499((R)-O-(2-Hexadecanamidoisohexyl) phosphocholine | ...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by Deoxycholate-phospholipid mixed micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004499((R)-O-(2-Hexadecanamidoisohexyl) phosphocholine | ...)
Affinity DataIC50:  300nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040462((R)-3-((S)-(E)-Dec-3-enoylamino)-5-methyl-hexanoic...)
Affinity DataIC50:  300nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50091800(2-amino-4-methylpyridine | 4-METHYLPYRIDIN-2-AMINE...)
Affinity DataIC50:  320nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50148162(4-(4-Methyl-pyridin-2-ylamino)-piperidine-1-carbox...)
Affinity DataIC50:  350nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040458((S)-4-((S)-(E)-Dec-3-enoylamino)-5-(naphthalen-2-y...)
Affinity DataIC50:  380nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36403((3R)-3-(1,2,3,4-Tetrahydroisoquinolin-7-yloxymethy...)
Affinity DataIC50:  400nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36400(CID24894151 | Ethyl 4-[(4-chloropyridin-2-yl)amino...)
Affinity DataIC50:  720nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50124535(1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[...)
Affinity DataIC50:  790nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36399(CID10221335 | N-[2-(6-Amino-4-methylpyridin-2-yl)e...)
Affinity DataIC50:  790nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040464((S)-3-((S)-(E)-Dec-3-enoylamino)-4-(naphthalen-2-y...)
Affinity DataIC50:  790nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36403((3R)-3-(1,2,3,4-Tetrahydroisoquinolin-7-yloxymethy...)
Affinity DataIC50:  1.00E+3nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36395(5-Fluoro-2-thiophen-2-yl-1,2-dihydroquinazolin-4-a...)
Affinity DataIC50:  1.00E+3nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM36398(4-(4'-Amino-1'-ethyl-5'-fluorospiro[pi...)
Affinity DataIC50:  1.20E+3nMpH: 7.0 T: 2°CAssay Description:Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040467((S)-5-((S)-Hexadecanoylamino)-7-methyl-octanoic ac...)
Affinity DataIC50:  1.30E+3nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50040459((R)-3-((S)-Decanoylamino)-5-methyl-hexanoic acid |...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and monomerically dispersed substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, major isoenzyme(Sus scrofa (pig))
Fisons

Curated by ChEMBL
LigandPNGBDBM50004504((R)-O-(2-Hexadecanamidopropyl] phosphocholine | CH...)
Affinity DataIC50:  1.40E+3nMAssay Description:In vitro inhibition of porcine pancreatic phospholipase A2 evaluated by monomeric substrate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040458((S)-4-((S)-(E)-Dec-3-enoylamino)-5-(naphthalen-2-y...)
Affinity DataIC50:  1.85E+3nMAssay Description:Compound was tested for in vitro activity against s-phospholipase A2 (s-PLA2) isolated from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
Fisons

Curated by ChEMBL
LigandPNGBDBM50040465((S)-3-((S)-(E)-Dec-3-enoylamino)-4-phenylsulfanyl-...)
Affinity DataIC50:  2.20E+3nMAssay Description:In vitro activity against porcine pancreatic phospholipase-A2 (PLA2) and micellar substrate with deoxycholate (DOC)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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