BindingDB PrimarySearch_ki

Found 610 with Last Name = 'gingipalli' and Initial = 'l'

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM138200(US8871778, 141)

IC50: 0.0300nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548361(CHEMBL4744190)

IC50: 0.0300nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548350(CHEMBL4780257)

IC50: 0.0600nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548354(CHEMBL4753469)

IC50: 0.0900nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548358(CHEMBL4753141)

IC50: 0.110nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548362(CHEMBL4784088)

IC50: 0.130nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548357(CHEMBL4752008)

IC50: 0.140nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548363(CHEMBL4753164)

IC50: 0.190nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553519(CHEMBL4758052)

IC50: 0.190nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548356(CHEMBL4792651)

IC50: 0.200nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553510(CHEMBL4740533)

IC50: 0.200nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548351(CHEMBL4786316)

IC50: 0.210nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50546407(CHEMBL4740065)

IC50: 0.210nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548353(CHEMBL4762290)

IC50: 0.220nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553508(CHEMBL4797815)

IC50: 0.220nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553502(CHEMBL4785413)

IC50: 0.230nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553500(CHEMBL4800498)

IC50: 0.240nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548355(CHEMBL4784783)

IC50: 0.240nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548360(CHEMBL4790107)

IC50: 0.260nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553520(CHEMBL4776734)

IC50: 0.300nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50546393(CHEMBL4751083)

IC50: 0.310nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50546393(CHEMBL4751083)

IC50: 0.310nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553504(CHEMBL4786007)

IC50: 0.330nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553506(CHEMBL4742918)

IC50: 0.340nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553507(CHEMBL4748041)

IC50: 0.340nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553501(CHEMBL4763433)

IC50: 0.360nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553521(CHEMBL4795975)

IC50: 0.400nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553517(CHEMBL4782062)

IC50: 0.510nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Details Article PubMed

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553512(CHEMBL4753097)

IC50: 0.600nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553514(CHEMBL4760325)

IC50: 0.730nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50546395(CHEMBL4796370)

IC50: 0.830nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553503(CHEMBL4741509)

IC50: 0.880nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548352(CHEMBL4793844)

IC50: 0.940nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50548359(CHEMBL4757235)

IC50: 0.950nMAssay Description:Inhibition of recombinant full length SYK (unknown origin) by biochemical Omnia assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Epidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50177903(CHEMBL3814825)

IC50: <1nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human EGFR T790M/L858R double mutant using biotinylated TK substrate incubated for 50 mins by HTRF as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553516(CHEMBL4758301)

IC50: 1.30nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553511(CHEMBL4743842)

IC50: 1.5nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553518(CHEMBL4760470)

IC50: 2.90nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Casein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50388781(CHEMBL2062585)

IC50: <3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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3D Structure (crystal)

Homeodomain-interacting protein kinase 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50460939(CHEMBL4228654)

IC50: <3nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

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Casein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50460945(CHEMBL4225287)

IC50: 3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Serine/threonine-protein kinase pim-3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50460939(CHEMBL4228654)

IC50: <3nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase TBK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL

PNG

BDBM50379339(CHEMBL2011940)

IC50: 3nMAssay Description:Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Casein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)

IC50: <3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

Casein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50437434(CHEMBL2409175)

IC50: <3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

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3D Structure (crystal)

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50553505(CHEMBL4741959)

IC50: 3.20nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Serine/threonine-protein kinase TBK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL

PNG

BDBM50379363(CHEMBL2011941)

IC50: 4nMAssay Description:Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid Similars

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Serine/threonine-protein kinase TBK1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL

PNG

BDBM50379357(CHEMBL2011933)

IC50: 4nMAssay Description:Inhibition of recombinant full-length TBK1 (unknown origin) using CK1tide as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Interleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50560889(CHEMBL4763746)

IC50: 4nMAssay Description:Inhibition of kinase tracer 236 binding to recombinant human full-length GST-tagged IRAK3 expressed in insect cells by Lanthascreen Eu kinase binding...More data for this Ligand-Target Pair

PDB NCI pathway
UniProtKB/SwissProt
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Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL

PNG

BDBM50246769(CHEMBL4064608)

IC50: 4nMAssay Description:Inhibition of recombinant human full-length His-tagged IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrat...More data for this Ligand-Target Pair

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3D Structure (crystal)

Displayed 1 to 50 (of 610 total ) | Next | Last >>

Filter my 610 hits

Targets 32▿
- Serine/threonine-protein kinase TBK1 120
- Epidermal growth factor receptor 73
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 58
- Tyrosine-protein kinase SYK 41
- DNA ligase 41
- Casein kinase II subunit alpha 40
- Cyclin-dependent kinase 2 37
- Aurora kinase B 36
- Potassium voltage-gated channel subfamily H member 2 33
- Interleukin-1 receptor-associated kinase 3 25
- Interleukin-1 receptor-associated kinase 4 24
- Serine/threonine-protein kinase pim-1 24
- Serine/threonine-protein kinase pim-2 24
- Interleukin-1 receptor-associated kinase 1 9
- Serine/threonine-protein kinase haspin 3
- Tyrosine-protein kinase ZAP-70 3
- Protein cereblon 3
- Cyclin-C/Cyclin-dependent kinase 19 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- NT-3 growth factor receptor 1
- Cyclin-C 1
- Insulin-like growth factor 1 receptor 1
- Serine/threonine-protein kinase pim-3 1
- Cyclin-dependent kinase 8 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Homeodomain-interacting protein kinase 2 1
- Cyclin-dependent kinase 19 1
- ALK tyrosine kinase receptor 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Glycogen synthase kinase-3 beta 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- ...
Publications 8▿
- Bioorg Med Chem Lett 22: 2063-9 (2012) 145
- Bioorg Med Chem Lett 24: 1138-43 (2014) 105
- Bioorg Med Chem Lett 28: 1336-1341 (2018) 99
- ACS Med Chem Lett 7: 514-9 (2016) 73
- J Med Chem 63: 10460-10473 (2020) 70
- Bioorg Med Chem Lett 30: (2020) 44
- Bioorg Med Chem Lett 25: 5172-7 (2015) 41
- Bioorg Med Chem Lett 30: (2020) 33
Institutions 2▿
- Astrazeneca 465
- Astrazeneca R&D Boston 145
Affinity: 0.030 to 2.0E+5 nM▿
- IC50 512
- Kd 9
- EC50 89
- Affinity ≤ nM
Xtal structures: 12
Docked structures: 0
Catalog Cmpds: 6