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Found 161 with Last Name = 'hamze' and Initial = 'a'
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564716(CHEMBL4790926)
Affinity DataIC50:  8nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM13065(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...)
Affinity DataIC50:  8.90nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564717(CHEMBL4787876)
Affinity DataIC50:  9nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50397360(CHEMBL2170177 | US10188756, Compound CN110)
Affinity DataIC50:  12nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564718(CHEMBL4781618)
Affinity DataIC50:  14nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564719(CHEMBL4793858)
Affinity DataIC50:  15nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  20nMAssay Description:Inhibition of HDAC6 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  29nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50029600(5-Bromo-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  30nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432281(CHEMBL2347671)
Affinity DataIC50:  50nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564720(CHEMBL4788045)
Affinity DataIC50:  59nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432287(CHEMBL2347677)
Affinity DataIC50:  60nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506580(CHEMBL4517272)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564720(CHEMBL4788045)
Affinity DataIC50:  64nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564720(CHEMBL4788045)
Affinity DataIC50:  70nMAssay Description:Inhibition of human GSK3alpha by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432286(CHEMBL2347667)
Affinity DataIC50:  70nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Paris-Sud University

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)
Affinity DataIC50:  72nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432280(CHEMBL2347672)
Affinity DataIC50:  80nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432285(CHEMBL2347668)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432279(CHEMBL2347673)
Affinity DataIC50:  110nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564716(CHEMBL4790926)
Affinity DataIC50:  117nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564716(CHEMBL4790926)
Affinity DataIC50:  121nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50592728(CHEMBL5183440)
Affinity DataIC50:  150nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432287(CHEMBL2347677)
Affinity DataIC50:  160nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564718(CHEMBL4781618)
Affinity DataIC50:  160nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564716(CHEMBL4790926)
Affinity DataIC50:  162nMAssay Description:Inhibition of human CDK2/cyclin A in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432281(CHEMBL2347671)
Affinity DataIC50:  170nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564717(CHEMBL4787876)
Affinity DataIC50:  195nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432286(CHEMBL2347667)
Affinity DataIC50:  210nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564719(CHEMBL4793858)
Affinity DataIC50:  216nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432278(CHEMBL2347674)
Affinity DataIC50:  240nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506582(CHEMBL4448903)
Affinity DataIC50:  240nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432280(CHEMBL2347672)
Affinity DataIC50:  240nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  272nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432284(CHEMBL2347669)
Affinity DataIC50:  280nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50592729(CHEMBL5199279)
Affinity DataIC50:  280nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432283(CHEMBL2346675)
Affinity DataIC50:  280nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Paris-Saclay

Curated by ChEMBL
LigandPNGBDBM50564718(CHEMBL4781618)
Affinity DataIC50:  284nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432277(CHEMBL2347675)
Affinity DataIC50:  310nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432282(CHEMBL2347670)
Affinity DataIC50:  310nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432285(CHEMBL2347668)
Affinity DataIC50:  320nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432276(CHEMBL2347676)
Affinity DataIC50:  320nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University Of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50432284(CHEMBL2347669)
Affinity DataIC50:  340nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506578(CHEMBL4542119)
Affinity DataIC50:  340nMAssay Description:Inhibition of HDAC8 (unknown origin) measured by fluorometry assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50506578(CHEMBL4542119)
Affinity DataIC50:  340nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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