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Found 115 with Last Name = 'hopkins' and Initial = 's'
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)
Affinity DataKi:  1.70nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataKi:  1.84nMAssay Description:Inhibition of calcineurin phosphatase activity of CyPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataKi:  2.64nMAssay Description:Inhibition of calcineurin phosphatase activity of CyPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260722(4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid...)
Affinity DataKi:  7.20nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50206007(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)
Affinity DataKi:  13nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433371(CHEMBL2375519)
Affinity DataKi:  190nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201010(((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  236nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201013(((2S,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  1.05E+3nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataKi:  2.00E+3nMAssay Description:Competitive inhibition of human recombinant DAAO by Michaelis-Menten plot analysis in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Sus scrofa (pig))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50004955(1H-Indole-2-carboxylic acid | CHEMBL278390 | Indol...)
Affinity DataKi:  3.40E+3nMAssay Description:Competitive inhibition of pig kidney DAAO in presence of D-alanineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201015(((2R,3aR,4R,6R,6aS)-6-(hydroxymethyl)-4-(5-methyl-...)
Affinity DataKi:  8.03E+3nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201012(((2R,3aR,4S,6R,6aR)-4-(hydroxymethyl)-6-(5-methyl-...)
Affinity DataKi:  3.34E+4nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201011(2-((2R,3aR,4R,6R,6aR)-4-(hydroxymethyl)-6-(5-methy...)
Affinity DataKi:  4.35E+4nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine phosphorylase(Homo sapiens (Human))
Attenuon

Curated by ChEMBL
LigandPNGBDBM50201014(((2S,3aR,4R,6R,6aS)-6-(hydroxymethyl)-4-(5-methyl-...)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human thymidine phosphorylase by continuous spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433372(CHEMBL2375520)
Affinity DataIC50:  3.10nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)
Affinity DataIC50:  5.40nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260725(4H-thieno[3,2-b]pyrrole-5-carboxylic acid | CHEMBL...)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of DAAO (unknown origin)More data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50260722(4-(4-chlorophenethyl)-1H-pyrrole-2-carboxylic acid...)
Affinity DataIC50:  11nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50206007(3-Hydroxy-chromen-2-one | 3-hydroxy-2H-chromen-2-o...)
Affinity DataIC50:  35nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50433371(CHEMBL2375519)
Affinity DataIC50:  219nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Sunovion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM36181(SODIUM BENZOATE | benzoate | benzoic acid | benzoi...)
Affinity DataIC50:  2.09E+3nMAssay Description:Competitive inhibition of human recombinant DAAO after 1 hr by coupled enzyme assay in presence of D-serineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of human recombinant CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of human recombinant CYP2C19 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataIC50:  1.24E+4nMAssay Description:Inhibition of human recombinant CYP2C19 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of human recombinant CYP2C9 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023584(CHEMBL3341839)
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of potassium channel IKs (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50:  3.88E+4nMAssay Description:Inhibition of human recombinant CYP2C9 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataIC50:  5.85E+4nMAssay Description:Inhibition of human recombinant CYP3A4 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50:  9.20E+4nMAssay Description:Inhibition of potassium channel Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023589(CHEMBL3355573)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Kv4.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50395399(CHEMBL2165063)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel HCN4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023585(CHEMBL3355578)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily D member 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023589(CHEMBL3355573)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Kv4.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023589(CHEMBL3355573)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel Cav3.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50023589(CHEMBL3355573)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of potassium channel HCN4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP1A2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023593(CHEMBL3355568)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP1A2 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Scynexis

Curated by ChEMBL
LigandPNGBDBM50323721((3S,6S,9S,12R,15S,18S,21S,24S,27S,30S,33S)-27-(2-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP2D6 after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023583(CHEMBL3355576)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023588(CHEMBL3355572)
Affinity DataIC50:  1.74E+5nMAssay Description:Inhibition of human ERG by cell-based patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily KQT member 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023582(CHEMBL3355575)
Affinity DataIC50: >3.33E+5nMAssay Description:Inhibition of potassium channel IKs (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50023582(CHEMBL3355575)
Affinity DataIC50: >3.33E+5nMAssay Description:Inhibition of potassium channel Kv1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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