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Found 141 with Last Name = 'houssin' and Initial = 'r'
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataKi:  2nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089984(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi:  10nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089996(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi:  13nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50119657(8-Butyl-7-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  14nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089987(4'-(1,4-Dioxo-3-pentyl-2,3-diaza-spiro[4.4]non-2-y...)
Affinity DataKi:  25nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089990(2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  25nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089990(2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  25nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089988(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi:  32nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089986(4'-(2,4-Dibutyl-4-methyl-3,5-dioxo-pyrazolidin-1-y...)
Affinity DataKi:  32nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089993(4'-(1,4-Dioxo-3-propyl-2,3-diaza-spiro[4.4]non-2-y...)
Affinity DataKi:  40nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089992(4'-(2-Butyl-4,4-dimethyl-3,5-dioxo-pyrazolidin-1-y...)
Affinity DataKi:  42nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50119658(7-Butyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  80nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089989(2-Phenyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataKi:  158nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089982(2-[2'-(1H-Tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-p-...)
Affinity DataKi:  381nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50090000(CHEMBL88471 | N-[4-(3-Butyl-1,4-dioxo-2,3-diaza-sp...)
Affinity DataKi:  398nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089981(2-Benzyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...)
Affinity DataKi:  402nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089991(2-[4-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089997(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi:  3.16E+3nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089998(2-[4-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089999(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089994(3-[4-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089995(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089983(2-Biphenyl-4-ylmethyl-3-butyl-2,3-diaza-spiro[4.4]...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50089985(4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-yl...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataIC50:  1nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  1nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  3nMAssay Description:The compound was evaluated for its inhibitory activity against 5-lipoxygenase using granulocytes-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50477671(CHEMBL250092)
Affinity DataIC50:  17nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50108781(2-{[1-(2-Amino-3-mercapto-propionyl)-piperidin-4-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50477675(CHEMBL376337)
Affinity DataIC50:  22nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50477678(CHEMBL251295)
Affinity DataIC50:  29nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50108780(2-{2-[4-(2-Amino-3-methylsulfanyl-propylamino)-3-m...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50156581(3-[3-fluoro-5-(4-methoxytetrahydropyran-4-yl)pheno...)
Affinity DataIC50:  36nMAssay Description:Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50477674(CHEMBL400918)
Affinity DataIC50:  43nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  45nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50477670(CHEMBL400385)
Affinity DataIC50:  45nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50477676(CHEMBL251503)
Affinity DataIC50:  45nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50477673(CHEMBL400415)
Affinity DataIC50:  47nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110484(3-((3-fluoro-5-(1-methoxycyclohexyl)phenoxy)methyl...)
Affinity DataIC50:  50nMAssay Description:The compound was evaluated for its inhibitory activity against Prostaglandin G/H synthase 2 using osteosarcomes cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048955((S)-2-[4-((R)-2-Amino-3-mercapto-propionylamino)-b...)
Affinity DataIC50:  72nMAssay Description:Inhibition of Farnesyltransferase catalyzed transfer of the FPP moiety to dansyl-GCVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50000829(6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)...)
Affinity DataIC50:  83nMAssay Description:Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110483(2-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50: <100nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110485(5-(4-Chloro-phenyl)-3-[3-fluoro-5-(4-methoxy-tetra...)
Affinity DataIC50: <100nMAssay Description:The compound was evaluated for prostaglandin E2 inhibition using recombinant Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50156577(1-(4-aminosulfonylphenyl)-3-[3-fluoro-5-(4-methoxy...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110485(5-(4-Chloro-phenyl)-3-[3-fluoro-5-(4-methoxy-tetra...)
Affinity DataIC50:  150nMAssay Description:Inhibition of 5-lipoxygenase activity of compound evaluated as determined by the inhibition of calcium ionophore-induced leukotriene B4 production in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50156584(1-(4-methanesulfonylphenyl)-3-[(3,4,5-trimethoxy)p...)
Affinity DataIC50:  220nMAssay Description:Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50477677(CHEMBL251711)
Affinity DataIC50:  285nMAssay Description:Inhibition of FTase by fluorescence spectrometry techniqueMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Laboratoires Innothera

Curated by ChEMBL
LigandPNGBDBM50110483(2-[3-Fluoro-5-(4-methoxy-tetrahydro-pyran-4-yl)-ph...)
Affinity DataIC50:  300nMAssay Description:The 5-lipoxygenase activity of the compound was determined by the inhibition of calcium ionophore-induced leukotriene B4 production in human blood.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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