Target
Type-1 angiotensin II receptor
Ligand
BDBM50089996
Substrate
n/a
Meas. Tech.
ChEMBL_36798 (CHEMBL650318)
Ki
13±n/a nM
Citation
 Le Bourdonnec, BMeulon, EYous, SGoossens, JFHoussin, RHénichart, JP Synthesis and pharmacological evaluation of new pyrazolidine-3, 5-diones as AT(1) angiotensin II receptor antagonists. J Med Chem 43:2685-97 (2000) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50089996
Synonyms:
4'-(3-Butyl-1,4-dioxo-2,3-diaza-spiro[4.4]non-2-ylmethyl)-biphenyl-2-sulfonic acid pentanoyl-amide | CHEMBL90872
Type:
Small organic molecule
Emp. Form.:
C29H37N3O5S
Mol. Mass.:
539.686
SMILES:
CCCCN1N(Cc2ccc(cc2)-c2ccccc2S(=O)(=O)NC(=O)CCCC)C(=O)C2(CCCC2)C1=O
Structure:
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