Compile Data Set for Download or QSAR
maximum 50k data
Found 2184 with Last Name = 'hurth' and Initial = 'k'
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US10035794, Example 31 | US10683287, Example 31 | ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrate with BACE-cleavable sequenceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US10035794, Example 31 | US10683287, Example 31 | ...)
Affinity DataIC50:  1nMAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337263(3-(2-chlorobenzyloxy)-2-(2-fluorophenyl)-2H-pyrazo...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US10035794, Example 31 | US10683287, Example 31 | ...)
Affinity DataIC50:  1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM84957(CGS 9896 | CHEMBL20042)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116254(US10035794, Example 31 | US10683287, Example 31 | ...)
Affinity DataIC50:  1nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50587074(CHEMBL5085959)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337263(3-(2-chlorobenzyloxy)-2-(2-fluorophenyl)-2H-pyrazo...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116236(US10035794, Example 11 | US10683287, Example 11 | ...)
Affinity DataIC50:  2nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM202490(US9539260, A3 | US9763952, Example A3)
Affinity DataIC50:  3nMT: 2°CAssay Description:Determination of Enzymatic PI3K Alpha and PI3K Delta Isoform Inhibition1.1 Test of Lipid Kinase ActivityThe efficacy of the compounds of examples 1-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116236(US10035794, Example 11 | US10683287, Example 11 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116247(US10035794, Example 24 | US10683287, Example 35 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type APP751 (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta42 levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells assessed as reduction in amyloid beta(1 to 40 residues) levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM134356(US8846658, 68)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM134359(US8846658, 71)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant BACE2 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM134348(US8846658, 60)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP expressed in CHO cells assessed as reduction in amyloid beta 40 secretion incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50012653(CHEMBL3261067)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP expressed in CHO cells assessed as reduction in amyloid beta 42 secretion incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM134401(US8846658, 118)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50273411(CHEMBL4127572)
Affinity DataIC50:  3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO cells co-expressing human APP751 assessed as decrease in amyloid beta 40 levels after 24 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM202490(US9539260, A3 | US9763952, Example A3)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM202513(US9539260, A12 | US9763952, Example A12)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204120(US9539260, K | US9763952, Example K)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203908(US9539260, C24 | US9539260, C25 | US9763952, Examp...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204008(US9539260, D12 | US9763952, Example D12)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204062(US9539260, D28 | US9539260, D29 | US9763952, Examp...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204070(US9539260, D35 | US9539260, D36 | US9763952, Examp...)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204077(US9539260, E3 | US9763952, Example E3)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204083(US9539260, E11 | US9763952, Example E11)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM341005(US9763952, Example E1 | US9763952, Example F1 | {(...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204087(US9539260, F4 | US9763952, Example F4)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204089(US9539260, F6 | US9763952, Example F6)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204090(US9539260, F7 | US9763952, Example F7)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204092(US9539260, F9 | US9763952, Example F9)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204093(US9539260, F10 | US9763952, Example F10)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204095(US9539260, F12 | US9763952, Example F12)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203425(US9539260, B79 | US9763952, Example B79)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203661(US9539260, B108 | US9763952, Example B108)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203662(US9539260, B109 | US9763952, Example B109)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203663(US9539260, B110 | US9763952, Example B110)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203396(US9539260, B52 | US9539260, B53 | US9763952, Examp...)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM204102(US9539260, H3 | US9539260, H4 | US9763952, Example...)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203381(US9539260, B38 | US9763952, Example B38)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203396(US9539260, B52 | US9539260, B53 | US9763952, Examp...)
Affinity DataIC50: <3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM203414(US9539260, B70 | US9763952, Example B70)
Affinity DataIC50:  3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116247(US10035794, Example 24 | US10683287, Example 35 | ...)
Affinity DataIC50:  3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116257(US10035794, Example 34 | US10683287, Example 34 | ...)
Affinity DataIC50:  3nMAssay Description:Chinese hamster ovary cells are transfected with the human gene for amyloid precursor protein. The cells are plated at a density of 8000 cells/well i...More data for this Ligand-Target Pair
In DepthDetails US Patent
Displayed 1 to 50 (of 2184 total ) | Next | Last >>
Jump to: