Found 681 with Last Name = 'keegan' and Initial = 's' TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.650nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate preincubated for 60 mins measured after 60 mins by ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.847nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.847nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.884nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of EGFR preincubated for 60 mins measured after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.53nMAssay Description:Inhibition of BMX relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55nMAssay Description:Inhibition of LYN-A expressed in Sf9 cells after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 1.82nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.89nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human full length PI3K p110delta/p85 alpha using PIP2/ATP as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.93nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Gilead Sciences
Curated by ChEMBL
Gilead Sciences
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMpH: 7.6Assay Description:The FLT3 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a HTRF kinase assay. The FLT3 enzyme (GST-FLT3 fusion) was purchased f...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
