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Found 49 with Last Name = 'kim' and Initial = 'tk'
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50474471(CHEMBL152133 | SK-7041)
Affinity DataIC50:  172nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50324675(2,2-diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-n...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Rad3-related (ATR) protein-mediated p53 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Korea Advanced Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50324675(2,2-diphenyl-N-(2,2,2-trichloro-1-(3-(4-fluoro-3-n...)
Affinity DataIC50:  200nMAssay Description:Inhibition of ataxia telangiectasia-mutatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50474470(CHEMBL152543 | SK-7068)
Affinity DataIC50:  205nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50123957((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...)
Affinity DataIC50:  233nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50474468(CHEMBL346525)
Affinity DataIC50:  371nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50340637(CHEMBL4163641)
Affinity DataIC50:  500nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50474467(CHEMBL152538)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50294526(CHEMBL551842 | cid_73157 | lobaric acid)
Affinity DataIC50:  800nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50340635(CHEMBL4174317)
Affinity DataIC50:  900nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM50474469(CHEMBL347068)
Affinity DataIC50:  942nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50294527(3-(1-butyl-1,6-dimethoxy-3-oxo-1,3-dihydroisobenzo...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50340636(SAKISACAULON A)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
In2Gen

Curated by ChEMBL
LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibitory activity against Histone deacetylase (HDAC) from SNU-16 (human gastric adenocarcinoma) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Korea Polar Research Institute

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of PTP1B (1 to 298 residues) (unknown origin) using p-nitrophenylphosphate as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50092821((R)-4-Ethyl-4-methyl-1,4a,12,13a-tetrahydro-4H-2-o...)
Affinity DataIC50:  4.00E+3nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099251(9,16-diethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahyd...)
Affinity DataIC50:  5.00E+3nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099248(1,9-diethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahydr...)
Affinity DataIC50:  1.20E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099250(2-[9-ethyl-9-hydroxy-10,13-dioxo-(9S)-2,3,9,10,13,...)
Affinity DataIC50:  1.60E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  2.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099246(9-ethyl-9-hydroxy-1-methyl-(9S)-2,3,9,10,13,15-hex...)
Affinity DataIC50:  2.10E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  4.00E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099244(9-ethyl-9-hydroxy-(9S)-2,3,9,10,13,15-hexahydro-1H...)
Affinity DataIC50:  4.10E+4nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099245(1-(2-aminoethyl)-9-ethyl-9-hydroxy-(9S)-2,3,9,10,1...)
Affinity DataIC50:  1.33E+5nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Life Science Research Center

Curated by ChEMBL
LigandPNGBDBM50099253(9,16-diethyl-9-hydroxy-1-methyl-(9S)-2,3,9,10,13,1...)
Affinity DataIC50:  1.60E+6nMAssay Description:Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184448(CHEMBL3822832)
Affinity DataEC50:  172nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184449(CHEMBL3823776)
Affinity DataEC50:  562nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124417(1Alpha,25-Dihydroxy-22-Oxavitamin D3 | 22-Oxacalci...)
Affinity DataEC50:  160nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  250nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184447(CHEMBL3822994)
Affinity DataEC50:  175nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184448(CHEMBL3822832)
Affinity DataEC50:  117nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184449(CHEMBL3823776)
Affinity DataEC50:  653nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  3.90nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124417(1Alpha,25-Dihydroxy-22-Oxavitamin D3 | 22-Oxacalci...)
Affinity DataEC50:  0.855nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124417(1Alpha,25-Dihydroxy-22-Oxavitamin D3 | 22-Oxacalci...)
Affinity DataEC50:  41nMAssay Description:Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  515nMAssay Description:Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124508(CHEMBL3623500)
Affinity DataEC50:  208nMAssay Description:Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124509(CHEMBL3623498)
Affinity DataEC50:  67nMAssay Description:Transactivation of VDR in human Caco2 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124509(CHEMBL3623498)
Affinity DataEC50:  65nMAssay Description:Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124508(CHEMBL3623500)
Affinity DataEC50:  271nMAssay Description:Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  322nMAssay Description:Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124417(1Alpha,25-Dihydroxy-22-Oxavitamin D3 | 22-Oxacalci...)
Affinity DataEC50:  38nMAssay Description:Transactivation of VDR in human HaCaT cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184447(CHEMBL3822994)
Affinity DataEC50:  241nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50200182((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Affinity DataEC50:  223nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50124417(1Alpha,25-Dihydroxy-22-Oxavitamin D3 | 22-Oxacalci...)
Affinity DataEC50:  145nMAssay Description:Activation of VDR in human Caco2 cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184447(CHEMBL3822994)
Affinity DataEC50:  203nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184448(CHEMBL3822832)
Affinity DataEC50:  31nMAssay Description:Activation of VDR in human Jurkat cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50184449(CHEMBL3823776)
Affinity DataEC50:  484nMAssay Description:Activation of VDR in human HaCaT cells expressing lentiviral VDRE-luciferase vector assessed as VDRE-mediated transcriptional activity measured after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed