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Found 1775 with Last Name = 'knight' and Initial = 'a'
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071733(CHEMBL413196 | Compound GRP)
Affinity DataKi:  0.0400nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071745(CHEMBL403317 | Compound NMB | Gly-Asn-Leu-Trp-Ala-...)
Affinity DataKi:  0.0680nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataKi:  0.100nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290967(1-{(5R,7S,8S)-8-[(2-Benzofuran-4-yl-acetyl)-methyl...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]-U-69,593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM85484(Bombesin)
Affinity DataKi:  0.150nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071735((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-pheny...)
Affinity DataKi:  0.150nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071739((S)-3-(1H-Indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl...)
Affinity DataKi:  0.170nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071750((S)-3-(1H-Indol-3-yl)-2-methyl-N-[1-(4-nitro-pheny...)
Affinity DataKi:  0.300nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity toward 5-HT2C receptor evaluated by displacement of [3H]-5-HT radioligand More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50169264((4R,10aR)-7-Chloro-4,6-dimethyl-1,2,3,4,10,10a-hex...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50200841(CHEMBL220360 | MK-0364 | MK-0634 | N-((2S,3S)-4-(4...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071746((S)-2-[3-(4-Cyano-phenyl)-ureido]-3-(1H-indol-3-yl...)
Affinity DataKi:  0.320nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM86237(CAS_8226 | METHYLERGONOVINE | NSC_8226)
Affinity DataKi:  0.350nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50031942((6aR,9R)-4,6a,7-Trimethyl-4,6,6a,7,8,9-hexahydro-i...)
Affinity DataKi:  0.360nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071748((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(4-nitro-pheny...)
Affinity DataKi:  0.390nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071736((S)-N-[1-(3,4-Dimethoxy-phenyl)-cyclohexylmethyl]-...)
Affinity DataKi:  0.440nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071743((S)-3-(1H-Indol-3-yl)-N-[1-(4-methoxy-phenyl)-cycl...)
Affinity DataKi:  0.460nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM86237(CAS_8226 | METHYLERGONOVINE | NSC_8226)
Affinity DataKi:  0.460nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071741((S)-N-[1-(4-Dimethylamino-phenyl)-cyclohexylmethyl...)
Affinity DataKi:  0.520nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071742((S)-N-[1-(4-Ethoxy-phenyl)-cyclohexylmethyl]-3-(1H...)
Affinity DataKi:  0.590nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071738((S)-N-[1-(4-Hydroxy-phenyl)-cyclohexylmethyl]-3-(1...)
Affinity DataKi:  0.620nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50088375(1-{8-[(2,3-Diphenyl-cycloprop-2-enecarbonyl)-methy...)
Affinity DataKi:  0.640nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]-U-69,593 to cloned rat Opioid receptor kappa 1 expressed in CHO cell lineMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.650nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50288252(Bombesin analogue | CHEMBL269432)
Affinity DataKi:  0.700nMAssay Description:Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human GRP(gastrin releasing peptide) receptors stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071744(AcBB(7-14) | CHEMBL314375)
Affinity DataKi:  0.700nMAssay Description:In vitro binding affinity at Bombesin BB2 receptor in the presence of [125I]-[Tyr] bombesin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50254012(3-(4-Amino-3-fluorobenzyl)-7-(2-furyl)-3H-[1,2,3]t...)
Affinity DataKi:  0.700nMAssay Description:Displacement of radioligand from human recombinant adenosine A2A receptor at 21 degC after 90 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50001707(10,17-dihydroxy-4-methyl-(13R,17S)-12-oxa-4-azapen...)
Affinity DataKi:  0.780nMAssay Description:Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MeP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM50179077((4R,9aR)-6-bromo-4-methyl-1,2,3,4,9,9a-hexahydro-2...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [3H]-5HT from human recombinant 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.930nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-B receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071737((S)-3-(1H-Indol-3-yl)-2-methyl-2-[3-(3-nitro-pheny...)
Affinity DataKi:  0.970nMAssay Description:Antagonism of recombinant human bombesin receptor (bb1) labeled with [125I]- [Tyr] bombesin stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  0.980nMMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM86529(CAS_113-15-5 | ERGOTAMINE | NSC_3251)
Affinity DataKi:  0.980nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377538(CHEMBL257757)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377543(CHEMBL260146)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377566(CHEMBL259049)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377567(CHEMBL409915)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
University Of California San Francisco

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataKi:  1nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377558(CHEMBL429144)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin-releasing peptide receptor(Homo sapiens (Human))
Cambridge University Forvie Site

Curated by ChEMBL
LigandPNGBDBM50071739((S)-3-(1H-Indol-3-yl)-N-[1-(5-methoxy-pyridin-2-yl...)
Affinity DataKi:  1nMAssay Description:Antagonistic activity against cloned human Bombesin receptor bb2 labeled with [125I]- [Tyr] bombesin stably expressed in CHO cells; 0.66-1.3More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50254353(3-(4-Amino-3-ethylbenzyl)-7-(2-furyl)-3H-[1,2,3]tr...)
Affinity DataKi:  1nMAssay Description:Displacement of radioligand from human recombinant adenosine A2A receptor at 21 degC after 90 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50239036(2-amino-N-benzyl-6-(furan-2-yl)-9H-purine-9-carbox...)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377556(CHEMBL411034)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50377557(CHEMBL264432)
Affinity DataKi:  1nMAssay Description:Binding affinity at human adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Vernalis Research

Curated by PDSP Ki Database
LigandPNGBDBM50249134(4-(4-fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2...)
Affinity DataKi:  1.07nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Vernalis R&D

Curated by ChEMBL
LigandPNGBDBM50254398(7-(2-Furyl)-3-(5-indolylmethyl)-3H-[1,2,3]triazolo...)
Affinity DataKi:  1.10nMAssay Description:Displacement of radioligand from human recombinant adenosine A2A receptor at 21 degC after 90 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM60212((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Affinity DataKi:  1.10nMAssay Description:Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MeP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Vernalis Research

Curated by ChEMBL
LigandPNGBDBM86427(CAS_50-37-3 | LSD | NSC_3981)
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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