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Found 64 with Last Name = 'kraus' and Initial = 'jl'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataIC50:  1nMAssay Description:Concentration required to inhibit HIV-1 protease cleavage by 50%.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM196(A-74704 | CHEMBL307193 | benzyl N-[(1S)-1-{[(2S,4S...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity of the compound was evaluated against HIV-protease was evaluatedMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091869(CHEMBL302464 | [(S)-1-Benzyl-2-oxo-2-((R)-3-oxo-2-...)
Affinity DataIC50:  8nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091868(CHEMBL294097 | [(S)-1-(4-Benzyloxy-benzyl)-2-oxo-2...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091876(CHEMBL445105 | [(S)-1-(4-Benzyloxy-benzyl)-2-oxo-2...)
Affinity DataIC50:  20nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091875(CHEMBL302902 | [(S)-1-(4-Hydroxy-benzyl)-2-oxo-2-(...)
Affinity DataIC50:  25nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091867(CHEMBL293394 | [(S)-1-(4-Hydroxy-benzyl)-2-oxo-2-(...)
Affinity DataIC50:  26nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16735(N-(2-{4-[(3R)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  46nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16733(4-[1-(5-Amino)-pentyl]-1-{4-(phenyl)-2-[(naphthale...)
Affinity DataIC50:  68nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16734(N-(2-{4-[(3S)-3-hydroxy-3-phenylpropyl]piperazin-1...)
Affinity DataIC50:  69nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16736(N-[2-(4-benzoylpiperazin-1-yl)-5-phenylphenyl]naph...)
Affinity DataIC50:  79nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16727(N-{5-bromo-2-[4-(2-hydroxyethyl)piperazin-1-yl]phe...)
Affinity DataIC50:  79nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16731(Naphthyl Compound, 5b | ethyl 2-{4-[2-(naphthalene...)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180393(CHEMBL205309 | tert-butyl 4-(4-bromo-2-(2-(7-metho...)
Affinity DataIC50:  93nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091870(CHEMBL294635 | N-[(S)-1-Benzyl-2-oxo-2-(3-oxo-2-ph...)
Affinity DataIC50:  100nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16732(1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-p...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16730(N-{2-[4-(2-hydroxyethyl)piperazin-1-yl]-5-phenylph...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16749(Coumarin Compound, 11c | N-[2-(4-benzylpiperazin-1...)
Affinity DataIC50:  151nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16729(N-[5-phenyl-2-(piperazin-1-yl)phenyl]naphthalene-1...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16750(2,2,2-trifluoroacetic acid; 2-oxo-N-[5-phenyl-2-(p...)
Affinity DataIC50:  580nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16742(Coumarin Compound, 9e | N-{5-bromo-2-[4-(2-hydroxy...)
Affinity DataIC50:  630nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  670nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16741(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  670nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16740(CHEMBL206442 | Coumarin Compound, 9c | N-[2-(4-ben...)
Affinity DataIC50:  760nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16740(CHEMBL206442 | Coumarin Compound, 9c | N-[2-(4-ben...)
Affinity DataIC50:  760nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16747(Coumarin Compound, 10e | N-{5-bromo-2-[4-(2-hydrox...)
Affinity DataIC50:  1.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16744(CHEMBL206854 | Coumarin Compound, 10b | tert-butyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16726(CHEMBL203120 | N-[5-bromo-2-(piperazin-1-yl)phenyl...)
Affinity DataIC50:  1.00E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16724(CHEMBL381618 | Naphthyl Compound, 3b | tert-butyl ...)
Affinity DataIC50: >1.00E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091873(CHEMBL63717 | [(S)-1-Benzyl-2-oxo-2-((S)-3-oxo-2-p...)
Affinity DataIC50:  1.00E+3nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16726(CHEMBL203120 | N-[5-bromo-2-(piperazin-1-yl)phenyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16739(CHEMBL207083 | Coumarin Compound, 9b | tert-butyl ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180395(CHEMBL205637 | N-(5-bromo-2-(4-(thiophen-2-ylsulfo...)
Affinity DataIC50:  1.13E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16728(N-[2-(4-benzylpiperazin-1-yl)-5-phenylphenyl]napht...)
Affinity DataIC50:  1.25E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50115670(CHEMBL115329 | {3-[(4-Amino-benzenesulfonyl)-isobu...)
Affinity DataIC50:  1.40E+3nMAssay Description:Concentration required to inhibit HIV-1 protease cleavage by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180396(4-Oxo-4H-chromene-2-carboxylic acid (5-bromo-2-pip...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16724(CHEMBL381618 | Naphthyl Compound, 3b | tert-butyl ...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180391(CHEMBL206651 | tert-butyl 4-(4-bromo-2-(quinoline-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180394(CHEMBL205241 | N-(5-bromo-2-piperazin-1-yl-phenyl)...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180398(CHEMBL206665 | tert-butyl 4-(4-bromo-2-(4-oxo-4H-c...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16744(CHEMBL206854 | Coumarin Compound, 10b | tert-butyl...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180399(CHEMBL206097 | N-(5-bromo-2-(4-(thiophen-2-ylsulfo...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM50180392(CHEMBL377745 | quinoline-2-carboxylic acid (5-brom...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16737(N-(2-{4-[5-(1,2-dithiolan-3-yl)pentanoyl]piperazin...)
Affinity DataIC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
University Of The Mediterranean

Curated by ChEMBL
LigandPNGBDBM50091871(CHEMBL302877 | Quinoline-2-carboxylic acid [(S)-1-...)
Affinity DataIC50:  5.00E+3nMAssay Description:Compound was evaluated for the inhibition of HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16745(CHEMBL381617 | Coumarin Compound, 10c | N-[2-(4-be...)
Affinity DataIC50: >5.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16746(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16746(2,2,2-trifluoroacetic acid; N-[5-bromo-2-(piperazi...)
Affinity DataIC50:  5.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Universite De La Mediterranee

LigandPNGBDBM16725(CHEMBL380521 | N-[2-(4-benzylpiperazin-1-yl)-5-bro...)
Affinity DataIC50: >5.00E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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