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Found 2467 with Last Name = 'lam' and Initial = 't'
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448761(CHEMBL3128021 | US8835445, 22)
Affinity DataKi:  0.00200nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448761(CHEMBL3128021 | US8835445, 22)
Affinity DataKi:  0.00200nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM131853(US8835445, 36)
Affinity DataKi:  0.00500nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448757(CHEMBL3128025 | US8835445, 18)
Affinity DataKi:  0.00500nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448757(CHEMBL3128025 | US8835445, 18)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552678(CHEMBL4759036)
Affinity DataKi:  0.00500nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448759(CHEMBL3128023 | US8835445, 17)
Affinity DataKi:  0.00700nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448759(CHEMBL3128023 | US8835445, 17)
Affinity DataKi:  0.00700nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448758(CHEMBL3128024)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552679(CHEMBL4762678)
Affinity DataKi:  0.00900nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552672(CHEMBL4790628)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448743(CHEMBL3128015)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0110nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448740(CHEMBL3128018)
Affinity DataKi:  0.0110nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM131845(US8835445, 23)
Affinity DataKi:  0.0110nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448756(CHEMBL3128026 | US8835445, 21)
Affinity DataKi:  0.0120nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448756(CHEMBL3128026 | US8835445, 21)
Affinity DataKi:  0.0120nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552676(CHEMBL4794635)
Affinity DataKi:  0.0130nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448744(CHEMBL3128014 | US8835445, 25 | US8835445, 34)
Affinity DataKi:  0.0160nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM131846(US8835445, 24)
Affinity DataKi:  0.0190nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448741(CHEMBL3128017)
Affinity DataKi:  0.0190nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351175(CHEMBL1818127 | US8835445, 30)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351175(CHEMBL1818127 | US8835445, 30)
Affinity DataKi:  0.0200nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM131850(US8835445, 32)
Affinity DataKi:  0.0210nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448753(CHEMBL3127912 | US8835445, 16)
Affinity DataKi:  0.0220nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448753(CHEMBL3127912 | US8835445, 16)
Affinity DataKi:  0.0220nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448738(CHEMBL3127909)
Affinity DataKi:  0.0240nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351173(CHEMBL1818129 | US8835445, 40)
Affinity DataKi:  0.0250nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351173(CHEMBL1818129 | US8835445, 40)
Affinity DataKi:  0.0250nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448751(CHEMBL3127914)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351174(CHEMBL1818128 | US8835445, 31)
Affinity DataKi:  0.0260nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50351174(CHEMBL1818128 | US8835445, 31)
Affinity DataKi:  0.0260nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448745(CHEMBL3128013 | US8835445, 26)
Affinity DataKi:  0.0300nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448745(CHEMBL3128013 | US8835445, 26)
Affinity DataKi:  0.0300nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552673(CHEMBL4750900)
Affinity DataKi:  0.0340nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552674(CHEMBL4742184)
Affinity DataKi:  0.0360nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM131854(US8835445, 37)
Affinity DataKi:  0.0390nMAssay Description:Antibacterial activity as measured by the minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations of compounds are well known...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448739(CHEMBL3128019)
Affinity DataKi:  0.0480nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
Philipps University

Curated by ChEMBL
LigandPNGBDBM50552677(CHEMBL4779067)
Affinity DataKi:  0.0770nMAssay Description:Inhibition of recombinant soluble human furin using Phac-Arg-Val-Arg-Arg-AMC fluorogenic substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM18070(5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM18070(5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...)
Affinity DataKi:  0.0810nMAssay Description:Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate a...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Staphylococcus aureus)
Trius Therapeutics

Curated by ChEMBL
LigandPNGBDBM50448760(CHEMBL3128022)
Affinity DataKi:  0.0960nMAssay Description:Inhibition of Staphylococcus aureus DHFR using dihydrofolate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometr...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM475643(US10851102, Example 36 | US11339160, Ex No. 36)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM475646(US10851102, Example 39 | US11339160, Ex No. 39)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM475648(US10851102, Example 41 | US11339160, Ex No. 41)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM475654(US10851102, Example 47 | US11339160, Ex No. 47)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM475655(US10851102, Example 48 | US11339160, Ex No. 48)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM608555(US11697648, Example 124)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM608556(US11697648, Example 125)
Affinity DataKi: <0.100nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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