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Found 530 with Last Name = 'le' and Initial = 'tb'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Affinity DataKi:  22.1nMAssay Description:Displacement of [3H]-WIN-35428 from human DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)
Affinity DataKi:  22.1nMAssay Description:Displacement of [3H]WIN35428 from human recombinant DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
TBA

Curated by ChEMBL
LigandPNGBDBM50280471((R)-6-((R)-(S)-1-Carboxy-3-phenyl-propylamino)-5-o...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibitory concentration of the compound against rabbit lung Angiotensin I converting enzyme (ACE)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000040(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.330nMAssay Description:Binding affinity against Neurokinin 1(NK1) receptor from human IM-9 cells using [I]-Bolton Hunter labeled SPMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-K receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50071484(CHEMBL308148 | N-[(R)-4-(4-Acetylamino-4-phenyl-pi...)
Affinity DataIC50:  0.440nMAssay Description:Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKAMore data for this Ligand-Target Pair
In DepthDetails Article
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134505(US8846656, 21-D)
Affinity DataIC50:  0.5nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134531(US8846656, 23-I)
Affinity DataIC50:  0.5nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134523(US8846656, 21-AL)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134574(US8846656, 55-I)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134511(US8846656, 21-Q)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134500(US8846656, 19-AF)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134518(US8846656, 21-AG)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134519(US8846656, 21-AH)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134530(US8846656, 23-H)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134512(US8846656, 21-R)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134589(US8846656, 65-I)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134596(US8846656, 69-L)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134586(US8846656, 65-A)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134524(US8846656, 21-AM)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134582(US8846656, 56-F)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134580(US8846656, 56-C)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134577(US8846656, 55-M)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134569(US8846656, 52-C)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134520(US8846656, 21-AI)
Affinity DataIC50:  1nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319577(3-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human NET-mediated norepinephrine uptake in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(HAMSTER)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50001447(CHEMBL217406 | His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu...)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-K receptor(HAMSTER)
Marion Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50001435(3-Amino-N-[1-(1-{1-[2-(1-{[(1-carbamoyl-2-phenyl-e...)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319582(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benzothiad...)
Affinity DataIC50:  1.10nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319587(CHEMBL1084042 | {3-[3-(2-Fluoro-phenyl)-2,2-dioxo-...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134525(US8846656, 22-C)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134551(US8846656, 32-B)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134572(US8846656, 55-G)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134581(US8846656, 56-E)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134591(US8846656, 68-B)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134587(US8846656, 65-B)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134590(US8846656, 65-K)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134571(US8846656, 54-B)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134579(US8846656, 56-B)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134498(US8846656, 19-AD)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134502(US8846656, 19-AI)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134546(US8846656, 29)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134509(US8846656, 21-N)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC5a anaphylatoxin chemotactic receptor 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134507(US8846656, 21-K)
Affinity DataIC50:  2nMAssay Description:Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319576(4-(2,2-Dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50319578((2S)-(4-[3-(2-Fluorophenyl)-2,2-dioxido-2,1,3-benz...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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