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Found 305 with Last Name = 'leung' and Initial = 'ik'
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataKi:  1.97E+3nMAssay Description:Competitive inhibition of human KDM2A expressed in Escherichia coli using 2-oxoglutarate by enzyme kinetic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555554(CHEMBL4751563)
Affinity DataKi:  6.40E+3nMAssay Description:Inhibition of Bacillus cereus phospholipase C by amplex red assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555553(CHEMBL4764001)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Bacillus cereus phospholipase C using L-alpha-phosphatidylcholine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target1-phosphatidylinositol phosphodiesterase(Bacillus cereus)
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM50555552(CHEMBL4785156)
Affinity DataKi:  7.10E+4nMAssay Description:Inhibition of Bacillus cereus PC-phospholipase C using phosphoryl-choline as substrate by molybdenum blue dye based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataKi:  8.50E+4nMAssay Description:Mixed type inhibition of human KDM2A expressed in Escherichia coli assessed inhibition constant for compound-enzyme-substrate complex using methyl ly...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50424584(CHEMBL2312530)
Affinity DataIC50:  20nMAssay Description:Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50303765(2-(3-hydroxy-2-((naphthalen-2-ylsulfonyl)carbonyli...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507151(CHEMBL4438274)
Affinity DataIC50:  26nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507140(CHEMBL4440514)
Affinity DataIC50:  35nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50:  63nMAssay Description:Inhibition of human KDM2A preincubated for 15 mins followed by substrate addition and measured after 30 mins using Biotin-H3(28-48)K36Me2 peptide as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507150(CHEMBL4440114)
Affinity DataIC50:  68nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human PHD2 catalytic domain (181 to 426) Mn2 expressed in Escherichia coli by NMR spectroscopic analysisMore data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606681(CHEMBL5219846)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507155(CHEMBL4587610)
Affinity DataIC50:  86nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM11995(2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic ac...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Tdp1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507156(CHEMBL4475772)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507139(CHEMBL4446104)
Affinity DataIC50:  158nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
University Of Oxford

LigandPNGBDBM50240426((2S,5R,6R)-6-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazi...)
Affinity DataIC50:  166nMpH: 7.2 T: 2°CAssay Description:An appropriate amount of enzyme (4uM) was pre-incubated with the (5R)- or 5(S)-penicilloic acid in the assay buffer (50mM HEPES-NaOH buffer (pH 7.2) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507153(CHEMBL4551119)
Affinity DataIC50:  172nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507152(CHEMBL4436400)
Affinity DataIC50:  192nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM3A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM4A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 6A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM6A (unknown origin) expressed in Escherichia coli using Biotin-H3(14-34)K27me3 peptide and measured after 1 hrs by alpha screen assa...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM6B (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM2A (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4B(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM4B (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM4C (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4D(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM4D (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM4E (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50396018(CHEMBL1230640)
Affinity DataIC50:  200nMAssay Description:Inhibition of KDM5C (unknown origin) expressed in Escherichia coli and measured after 1 hrs by alpha screen assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50:  200nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50:  250nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606682(CHEMBL5220094)
Affinity DataIC50:  330nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM81347(L2037 (beta-lapachone))
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant human Tdp1 using 5'-biotin-GATCTAAAAGACTT-pY-3' as substrate measured after 20 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395078(CHEMBL2164245)
Affinity DataIC50:  370nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4E(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50129197(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human KDM4E expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50596053(CHEMBL5173876)
Affinity DataIC50:  400nMAssay Description:Inhibition of human KDM3A preincubated for 15 mins followed by substrate addition and measured after 5 mins using H3(1-21)K9Me2-GGK-Biotin peptide as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606686(CHEMBL5219336)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50129197(4-(Hydroxyamino)-4-oxobutanoic acid | CHEMBL51979 ...)
Affinity DataIC50:  430nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507154(CHEMBL4533174)
Affinity DataIC50:  457nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50:  480nMAssay Description:Inhibition of human KDM5C catalytic domain expressed in Sf9 cells using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395083(CHEMBL2164246)
Affinity DataIC50:  480nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50277935((S)-2-(1-chloro-4-hydroxyisoquinoline-3-carboxamid...)
Affinity DataIC50:  512nMAssay Description:Inhibition of human PHD2 at 293K temperature by solvent relaxation techniqueMore data for this Ligand-Target Pair
TargetHistone lysine demethylase PHF8(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)
Affinity DataIC50:  550nMAssay Description:Inhibition of human PHF8 expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50197063(4,6-dioxoheptanoic acid | CHEMBL222824 | succinyla...)
Affinity DataIC50:  570nMAssay Description:Inhibition of human KDM2A expressed in Escherichia coli using methyl lysine peptide substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50507148(CHEMBL4455616)
Affinity DataIC50:  610nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21 (DE3) using 5'-(5,6 FAM-aac gtc agg gtc ttc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606684(CHEMBL5220148)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50606685(CHEMBL5219099)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant full length N-terminal hexahistidine-tagged human FTO expressed in Escherichia coli BL21 (DE3) incubated for 10 mins using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosyl-DNA phosphodiesterase 1(Homo sapiens (Human))
Siberian Branch Of The Russian Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50388602(FURAMIDINE)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged Tdp1 expressed in Escherichia coli BL21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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