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Found 99 with Last Name = 'mak' and Initial = 'jy'
TargetFe(3+)-Zn(2+) purple acid phosphatase(Phaseolus vulgaris)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50254627((+/-)-decyloxy(naphthalen-1-yl)methylphosphonic ac...)
Affinity DataKi:  4.00E+3nMpH: 6.2Assay Description:Inhibition of red kidney bean PAP at pH 6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFe(3+)-Zn(2+) purple acid phosphatase(Phaseolus vulgaris)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50254626((+/-)-naphthalen-1-yl(octyloxy)methylphosphonic ac...)
Affinity DataKi:  5.00E+4nMpH: 6.2Assay Description:Inhibition of red kidney bean PAP at pH 6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFe(3+)-Zn(2+) purple acid phosphatase(Phaseolus vulgaris)
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50254498((+/-)-hexyloxy(naphthalen-1-yl)methylphosphonic ac...)
Affinity DataKi:  1.47E+6nMpH: 6.2Assay Description:Inhibition of red kidney bean PAP at pH 6.2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563275(CHEMBL4761013)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM22449(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of recombinant human HDAC6 using Boc-Lys(Ac)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563275(CHEMBL4761013)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50:  12nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563274(CHEMBL4799406)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563274(CHEMBL4799406)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50:  18nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563274(CHEMBL4799406)
Affinity DataIC50:  24nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563286(CHEMBL4776127)
Affinity DataIC50:  31nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563275(CHEMBL4761013)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563274(CHEMBL4799406)
Affinity DataIC50:  46nMAssay Description:Inhibition of recombinant human HDAC9 using Ac-LGK(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563275(CHEMBL4761013)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563285(CHEMBL4762512)
Affinity DataIC50:  49nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563275(CHEMBL4761013)
Affinity DataIC50:  71nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563273(CHEMBL4748500)
Affinity DataIC50:  72nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563288(CHEMBL4776962)
Affinity DataIC50:  76nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563274(CHEMBL4799406)
Affinity DataIC50:  88nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  100nMAssay Description:Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  109nMAssay Description:Agonist activity at human PAR2 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 20 mins followed by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563287(CHEMBL4752663)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563285(CHEMBL4762512)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-LGK(Ac)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 90...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human HDAC8 using Ac-LGK(TFA)-AMC as substrate preincubated for 30 mins followed by substrate addition and measured after 9...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50:  216nMAssay Description:Inhibition of recombinant human HDAC5 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563290(CHEMBL4784844)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/2/3/8(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50:  300nMAssay Description:Inhibition of Class 1 histone deacetylase in human THP-1 cells using Ac-LGK(Ac)-AMC as substrate incubated for 3 hrs followed by 50 uM SAHA addition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563276(CHEMBL4751615)
Affinity DataIC50:  354nMAssay Description:Inhibition of recombinant human HDAC4 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563280(CHEMBL4759268)
Affinity DataIC50:  360nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50475225((S)-HDAC 42 | (S)-HDAC-42 | AR42 | Ar-42)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563291(CHEMBL4776825)
Affinity DataIC50:  620nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440863(CHEMBL2431716)
Affinity DataIC50:  700nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563279(CHEMBL4751174)
Affinity DataIC50:  890nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563289(CHEMBL4792528)
Affinity DataIC50:  950nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563283(CHEMBL4748151)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563284(CHEMBL4760192)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440868(CHEMBL2431617)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50440868(CHEMBL2431617)
Affinity DataIC50:  1.10E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50203292(CHEMBL3902670)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteinase-activated receptor 2(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50203292(CHEMBL3902670)
Affinity DataIC50:  1.26E+3nMAssay Description:Antagonist activity at PAR2 in human HT-29 cells assessed as inhibition of 2f-LIGRLO-NH2-stimulated intracellular calcium release preincubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
The University Of Queensland

Curated by ChEMBL
LigandPNGBDBM50563292(CHEMBL4747652)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant human HDAC7 using Ac-LGK(TFA)-AMC as substrate pre-incubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
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