Affinity DataIC50: 2nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibitory activity of the compound towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibitory activity towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
TargetHistone deacetylase(Rattus norvegicus)
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibitory activity against rat liver Histone deacetylase with substrate 5bMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibitory activity of the compound towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
TargetHistone deacetylase(Rattus norvegicus)
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 3aMore data for this Ligand-Target Pair
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cellsMore data for this Ligand-Target Pair
TargetHistone deacetylase(Rattus norvegicus)
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 3bMore data for this Ligand-Target Pair
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of GCN2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assayMore data for this Ligand-Target Pair
TargetHistone deacetylase(Rattus norvegicus)
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against rat liver histone deacetylase (HDAC) with substrate 12aMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity towards human recombinant fibroblast collagenaseMore data for this Ligand-Target Pair
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against IgE receptorMore data for this Ligand-Target Pair
TargetLow affinity immunoglobulin epsilon Fc receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Smithkline Beecham Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cellsMore data for this Ligand-Target Pair