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Found 189 with Last Name = 'mastroianni' and Initial = 'd'
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.140nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.140nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22872(1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...)
Affinity DataKi:  0.230nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137975(7-Bromo-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza...)
Affinity DataKi:  0.25nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  0.300nMAssay Description:Half-maximal inhibition of [3H]7-OH-DPAT binding to Histamine H1 receptor in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  0.330nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  0.330nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137981(7-Chloro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  0.340nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137972(7-Fluoro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  0.350nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.400nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.400nMAssay Description:Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  0.400nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137981(7-Chloro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  0.430nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137975(7-Bromo-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza...)
Affinity DataKi:  0.450nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137976(9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f...)
Affinity DataKi:  0.5nMAssay Description:In vitro binding affinity towards alpha-1 adrenergic receptor in rat frontal cortex homogenate using of [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22872(1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...)
Affinity DataKi:  0.5nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137976(9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f...)
Affinity DataKi:  0.650nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137978((S)-7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihy...)
Affinity DataKi:  0.820nMAssay Description:In vitro binding affinity towards alpha-1 adrenergic receptor in rat frontal cortex homogenate using of [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137975(7-Bromo-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza...)
Affinity DataKi:  0.830nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50028601(1-(8-Chloro-5H-dibenzo[a,d]cyclohepten-10-yl)-4-me...)
Affinity DataKi:  1nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137980(1-Methyl-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137976(9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in human using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50066910((+/-)7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dih...)
Affinity DataKi:  1.14nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137978((S)-7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dihy...)
Affinity DataKi:  1.5nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50137981(7-Chloro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  1.90nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  1.90nMAssay Description:Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007568(1-((S)-8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-...)
Affinity DataKi:  1.90nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  2nMAssay Description:Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137981(7-Chloro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM22872(1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...)
Affinity DataKi:  2.30nMAssay Description:Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM22872(1-(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-y...)
Affinity DataKi:  2.40nMAssay Description:Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137972(7-Fluoro-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity towards Dopamine receptor D3 in Sf9 cell membranes using [3H]7-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50137980(1-Methyl-9-(4-methyl-piperazin-1-yl)-4-thia-10a-az...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50137976(9-(4-Methyl-piperazin-1-yl)-4-thia-10a-aza-benzo[f...)
Affinity DataKi:  2.70nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Affinity DataKi:  2.90nMAssay Description:In vitro binding affinity towards Histamine H1 receptor of rat frontal cortex homogenate by using radioligand [3H]pyrilamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108590((+/-)7-Chloro-9-(4-ethyl-piperazin-1-yl)-9,10-dihy...)
Affinity DataKi:  3.10nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Universit£

Curated by ChEMBL
LigandPNGBDBM50137975(7-Bromo-9-(4-methyl-piperazin-1-yl)-4-thia-10a-aza...)
Affinity DataKi:  3.40nMAssay Description:In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50137982(7-Chloro-9-(4-methyl-[1,4]diazepan-1-yl)-4-thia-10...)
Affinity DataKi:  3.5nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in rat tissue homogenate using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108595((+/-)7-Bromo-9-(4-methyl-piperazin-1-yl)-9,10-dihy...)
Affinity DataKi:  3.60nMAssay Description:Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007567(1-(8-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-y...)
Affinity DataKi:  3.60nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108596((+/-)2-[4-(7-Chloro-9,10-dihydro-4-thia-10a-aza-be...)
Affinity DataKi:  3.60nMAssay Description:Half-maximal inhibition of [3H]-7-OH-DPAT binding to Dopamine receptor D3 in rat tissue homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108595((+/-)7-Bromo-9-(4-methyl-piperazin-1-yl)-9,10-dihy...)
Affinity DataKi:  3.60nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  3.70nMAssay Description:In vitro binding affinity towards Dopamine receptor D2 in human using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50066910((+/-)7-Chloro-9-(4-methyl-piperazin-1-yl)-9,10-dih...)
Affinity DataKi:  3.80nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50108597((+/-)7-Bromo-9-(4-ethyl-piperazin-1-yl)-9,10-dihyd...)
Affinity DataKi:  4nMAssay Description:Half-maximal inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  4nMAssay Description:Half-maximal inhibition of [3H]ketanserin binding to 5-hydroxytryptamine 2A receptor in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)
Affinity DataKi:  4nMAssay Description:In vitro binding affinity towards 5-hydroxytryptamine 2A receptor in rat tissue homogenate using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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