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Found 45 with Last Name = 'mclean' and Initial = 'ew'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4690((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00000600nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042365(CHEMBL117417 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033660(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033663(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  5.20nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042370(CHEMBL326595 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  5.80nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042364(CHEMBL327010 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033661(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  10nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033666(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Affinity DataKi:  11nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042372(CHEMBL117127 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  13nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042363(CHEMBL333946 | {2-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  35nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042367(CHEMBL325716 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  60nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042369(CHEMBL119243 | {2-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  69nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033664(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  100nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042362(CHEMBL331133 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  150nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033663(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  390nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042366(CHEMBL116580 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  600nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033660(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  900nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042361(CHEMBL324839 | {3-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033665(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033661(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033662(CHEMBL7194 | {Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chlorideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033664(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042360(CHEMBL117588 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042368(CHEMBL446671 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033665(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50033662(CHEMBL7194 | {Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihy...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Burroughs Wellcome

Curated by ChEMBL
LigandPNGBDBM50042371(CHEMBL327003 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)
Affinity DataIC50:  200nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase B (MAO-B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  700nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  700nMAssay Description:Inhibition activity against Glycinamide ribonucleotide transformylase(GAR-TFase) against hog liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  1.90E+3nMAssay Description:Triglutamyl homologue inhibition activity against AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014844(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition activity against Glycinamide ribonucleotide transformylase(GAR-TFase) from L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase A (MAO-A)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014843(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition activity against Glycinamide ribonucleotide transformylase(GAR-TFase) against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014843(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition activity against AICAR formyltransferase determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein-lysine 6-oxidase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory concentration of the compound against lysyl oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014844(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition activity against AICAR formyltransferase from hog liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  9.40E+4nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005520((S)-2-{4-[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimid...)
Affinity DataIC50:  2.00E+5nMAssay Description:Inhibition activity against AICAR formyltransferase determined against MOLT-4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014843(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  2.80E+5nMAssay Description:Inhibition activity against AICAR formyltransferase determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Mus musculus)
Wellcome Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50014843(2-(4-{[3-(2,4-Diamino-6-oxo-1,6-dihydro-pyrimidin-...)
Affinity DataIC50:  5.74E+5nMAssay Description:Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed