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Found 596 with Last Name = 'meudal' and Initial = 'h'
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092393(3-(2-{[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-su...)
Affinity DataKi:  0.150nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092405((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Affinity DataKi:  0.280nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM21147((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092393(3-(2-{[2-(2-{2-[2-tert-Butoxycarbonylamino-3-(4-su...)
Affinity DataKi:  0.310nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50449787(CHEMBL2062154 | PD-134308)
Affinity DataKi:  0.400nMAssay Description:Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50061266((2R,4R)-1-[(R)-2-(2-Aza-tricyclo[3.3.1.1*3,7*]dec-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092408(CHEMBL120150 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-(2...)
Affinity DataKi:  0.540nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM21147((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Affinity DataKi:  0.600nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092405((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Affinity DataKi: >0.700nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM21147((3S)-3-[(2S)-2-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(3S)-3-...)
Affinity DataKi:  0.700nMAssay Description:Compound was tested for binding affinity against CCK1 (cholecystokinin) receptor on guinea pig pancreatic membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092398((S)-3-((S)-2-{[(S)-2-tert-Butoxycarbonylamino-3-(1...)
Affinity DataKi: >0.700nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092405((S)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-((S)-2-{[...)
Affinity DataKi:  0.75nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092398((S)-3-((S)-2-{[(S)-2-tert-Butoxycarbonylamino-3-(1...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50083386(1-{[1-(2,3-Dicarboxy-pyrrolidine-1-carbonyl)-2-met...)
Affinity DataKi:  0.873nMAssay Description:Binding affinity against recombinant Aminopeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087104(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Affinity DataKi:  0.940nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092388(3-(2-{[2-(3-tert-Butoxycarbonylamino-propionylamin...)
Affinity DataKi:  1.35nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092387(CHEMBL118610 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-(2...)
Affinity DataKi:  1.37nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087088((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21649((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-(4-phenylpheny...)
Affinity DataKi:  1.5nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21639((2S)-2-[2-(2,3-dihydro-1H-inden-1-yl)-3-sulfanylpr...)
Affinity DataKi:  1.80nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092399(3-(2-{[2-(2-Benzylcarbamoyl-acetylamino)-3-(1H-ind...)
Affinity DataKi:  1.81nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087095(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50061270((2R,4R)-1-[(R)-2-(2-Aza-tricyclo[3.3.1.1*3,7*]dec-...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity (affinity state 1) for Cholecystokinin type B receptor, was determined using CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087113((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
Cnrs

LigandPNGBDBM21642((2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolid...)
Affinity DataKi:  2nMAssay Description:Specific activity of ACE was assayed in black 96-well microplates with or without various concentrations of inhibitors. N-Cbz-Phe-His-Leu was added, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataKi:  2nMAssay Description:Compound was tested for the affinity against Cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092391(3-(2-{[2-(2-Carbamoyl-acetylamino)-3-(1H-indol-3-y...)
Affinity DataKi:  2.05nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21654((2S)-2-[(2S)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  2.10nM ΔG°:  -51.5kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087097(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21643(CGS-31,447 | [3-(naphthalen-1-yl)-1-{[(1S)-2-(4-ph...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21644((2S)-3-(1H-indol-3-yl)-2-[(2S,3S)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.20nM ΔG°:  -51.4kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087084(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087093(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087094((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21645((2S)-3-(1H-indol-3-yl)-2-[(2R,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.40nM ΔG°:  -51.2kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21646((2S)-3-(1H-indol-3-yl)-2-[(2S,3R)-3-phenyl-2-(sulf...)
Affinity DataKi:  2.5nM ΔG°:  -51.1kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092404(CHEMBL261934 | N-(1-Carbamoyl-2-phenyl-ethyl)-3-(2...)
Affinity DataKi:  2.52nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(RAT)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092398((S)-3-((S)-2-{[(S)-2-tert-Butoxycarbonylamino-3-(1...)
Affinity DataKi:  2.60nMAssay Description:Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(Cavia porcellus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092396(3-(2-{[2-Amino-3-(1H-indol-3-yl)-propionyl]-methyl...)
Affinity DataKi:  2.60nMAssay Description:Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50092410(2-tert-Butoxycarbonylamino-N-[1-({1-[1-(1-carbamoy...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity against cholecystokinin type B receptor on guinea pig cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM50087100((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21657((2S)-3-(1H-indol-3-yl)-2-[(2R)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Cnrs

LigandPNGBDBM21658((2S)-3-(1H-indol-3-yl)-2-[(2S)-3-sulfanyl-2-[(1R)-...)
Affinity DataKi:  3nM ΔG°:  -50.6kJ/molepH: 7.4 T: 2°CAssay Description:NEP was preincubated in black 96-well microplates with or without increasing concentrations of inhibitors. DGPA was added, and the reaction was stopp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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