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Found 303 with Last Name = 'mignani' and Initial = 's'
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50470454(CHEMBL4282040)
Affinity DataKi:  650nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA substrate incubated for 30 mins by Michaelis-Menten kinetics analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047103(2-{3-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047108(2-{2-[4-(6-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047089(2-{3-[4-(5-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047092(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047100(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280830(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  0.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047086(2-{3-[4-(1-Methyl-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047097(2-{2-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047110(2-{4-[4-(1H-Indol-3-yl)-3,6-dihydro-2H-pyridin-1-y...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283917(1-(1,1-Diphenyl-silolan-3-yl)-4-(4-fluoro-phenyl)-...)
Affinity DataIC50:  0.900nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283931(1-(1,1-Diphenyl-silolan-3-yl)-4-phenyl-piperazine ...)
Affinity DataIC50:  1nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250824(CHEMBL4101278)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50280826(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280822(4-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047091(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-3,6-dihydro...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50047098(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.20nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047098(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047106(2-{3-[4-(5-Chloro-1H-indol-3-yl)-3,6-dihydro-2H-py...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047105(2-(2-{4-[2-(5-Fluoro-1H-indol-3-yl)-ethyl]-piperid...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280819(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.5nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50029154(5-Fluoro-3-piperidin-4-ylmethyl-1H-indole | CHEMBL...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Affinity DataIC50:  1.70nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047102(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280831(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  1.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047109(2-{3-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  2nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Centre De Recherche De Paris

Curated by ChEMBL
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)
Affinity DataIC50:  2nMAssay Description:Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283920(1-[1,1-Bis-(4-fluoro-phenyl)-silolan-3-yl]-4-pheny...)
Affinity DataIC50:  2nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280817(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  2.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280828(3-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  2.60nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase A(Homo sapiens (Human))
Centre De Recherche De Paris

Curated by ChEMBL
LigandPNGBDBM50136490(CHEMBL3038087 | Cyclosporin A analogue)
Affinity DataIC50:  3nMAssay Description:Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250823(CHEMBL4065940)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Centre De Recherche De Paris

Curated by ChEMBL
LigandPNGBDBM50136490(CHEMBL3038087 | Cyclosporin A analogue)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity against HIV-1 RT in CEM4 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283920(1-[1,1-Bis-(4-fluoro-phenyl)-silolan-3-yl]-4-pheny...)
Affinity DataIC50:  3nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280824(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.10nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50283928(1-(1,1-Diphenyl-silolan-3-yl)-4-(3-fluoro-phenyl)-...)
Affinity DataIC50:  3.40nMAssay Description:In vitro binding affinity towards serotonin 5-HT2A receptor in rat cortical membranes using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
LigandPNGBDBM50280823(1-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.70nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50280832(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  3.80nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047107(2-{2-[4-(5-Fluoro-1H-indol-2-ylmethyl)-piperidin-1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250837(CHEMBL4063017)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280827(1'-{2-[4-(5-fluoro-1H-3-indolylmethyl)hexahydro-1-...)
Affinity DataIC50:  4nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250815(CHEMBL4089950)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047095(2-{3-[4-(1H-Indol-3-yl)-piperidin-1-yl]-propyl}-2H...)
Affinity DataIC50:  4.60nMAssay Description:Binding affinity at dopamine receptor D2 by the inhibition of binding to [3H]-spiperone in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047085(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperazin-1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250825(CHEMBL4074567)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250814(CHEMBL4068858)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Centre De Recherches De Vitry-Alfortville

Curated by ChEMBL
LigandPNGBDBM50047088(2-{2-[4-(3H-Inden-1-ylmethyl)-piperidin-1-yl]-ethy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-peroxitine binding to rat cortical membranes as measure of inhibitory activity towards 5-HT uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50280829(2-{2-[4-(5-Fluoro-1H-indol-3-ylmethyl)-piperidin-1...)
Affinity DataIC50:  5.40nMAssay Description:Compound was evaluated for inhibition of 5-HT uptake by measuring its ability to inhibit [3H]paroxetine binding to rat cortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50250813(CHEMBL4095226)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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