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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50283917
Substrate
n/a
Meas. Tech.
ChEMBL_201054 (CHEMBL805830)
IC50
0.9±n/a nM
Citation
 Damour, D; Barreau, M; Dutruc-Rosset, G; Doble, A; Piot, O; Mignani, S 1,1-diphenyl-3-dialkylamino-1-silacyclopentane derivatives: A new class of potent and selective 5-HT2A antagonists Bioorg Med Chem Lett 4:415-420 (1994)    Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52852.05
Organism:
Rattus norvegicus (rat)
Description:
Rat cortex membranes 5-HT2A receptors.
Residue:
471
Sequence:
MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYKSSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
  
Inhibitor
Name:
BDBM50283917
Synonyms:
1-(1,1-Diphenyl-silolan-3-yl)-4-(4-fluoro-phenyl)-piperazine | CHEMBL337226
Type:
Small organic molecule
Emp. Form.:
C26H29FN2Si
Mol. Mass.:
416.6058
SMILES:
Fc1ccc(cc1)N1CCN(CC1)C1CC[Si](C1)(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: