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Found 22 with Last Name = 'miranda' and Initial = 'al'
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50060964((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]prazosin from rat salivary gland adrenergic alpha 1A receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]prazosin from rat salivary gland adrenergic alpha 1A receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataKi:  5.55nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataIC50:  0.269nMAssay Description:Displacement of [3H]prazosin from rat salivary gland adrenergic alpha 1A receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataIC50:  0.851nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataIC50:  6.03nMAssay Description:Displacement of [3H]prazosin from rat liver adrenergic alpha1B receptor after 45 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human CHK2 kinase expressed in insect Sf21 cells using phospho-CREBtide as substrate at 30 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant IKK-alpha expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Affinity DataIC50:  490nMAssay Description:Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrate at 30 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Federal University Of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50254291(2-(4-(Methylsulfonyl)phenyl)-N-(4-methoxyphenyl)-i...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of PGHS2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Federal University Of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of PGHS2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Federal University Of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50255143(CHEMBL482199 | N-(6-(2-benzylidenehydrazinecarbony...)
Affinity DataIC50:  4.10E+3nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Federal University Of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50255143(CHEMBL482199 | N-(6-(2-benzylidenehydrazinecarbony...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of COX2 in LPS-stimulated human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50056999(CHEMBL56367 | nimesulide)
Affinity DataIC50:  1.09E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 13(Mus musculus)
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50485275(CHEMBL2043204 | LASSBio-998)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of LPS-induced p38 MAPK activation in BALB/c mouse peritoneal macrophagesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Federal University Of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50254238(2-Phenyl-N-(2-pyridinyl)imidazo[1,2-a]pyridin-3-am...)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of PGHS2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50340790((E)-N-(4-nitrobenzylidene)-2-naphthohydrazide | CH...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human recombinant IKK-beta expressed in insect Sf21 cells using phospho-Ulight-IkappaB-alpha as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKd:  0.170nMAssay Description:Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50026917(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Affinity DataKd:  3.02nMAssay Description:Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Rattus norvegicus (Rat))
Universidade Federal Do Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM50393116(CHEMBL2153423)
Affinity DataKd:  0.0251nMAssay Description:Antagonist activity at adrenergic alpha 1D receptor in rat thoracic aorta assessed as inhibition of noradrenaline-induced contraction after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed