TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 74nM ΔG°: -40.3kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 74nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 88nM ΔG°: -39.9kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 971nM ΔG°: -34.0kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Consiglio Nazionale Delle Ricerche
Consiglio Nazionale Delle Ricerche
Affinity DataKi: 971nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated with compound for 20 mins followed by substrate addition measured after 120 mins in presence of...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of PI3Kalpha (unknown origin) preincubated with compound for 20 mins followed by substrate addition measured after 120 mins in presence of...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 350nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 470nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Pharmaron Beijing
Curated by ChEMBL
Pharmaron Beijing
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidy...More data for this Ligand-Target Pair
TargetPeptidoglycan D,D-transpeptidase FtsI(Pseudomonas aeruginosa)
Louis Stokes Cleveland Department Of Veterans Affairs Medical Center
Curated by ChEMBL
Louis Stokes Cleveland Department Of Veterans Affairs Medical Center
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa PBP3 assessed as reduction in fluorescence intensity of bocillin labeled protein pre-incubated for 20 mins befor...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:SPA assays were run in displacement mode using 30 nM [3H]-GW3965. Ligands were tested in 12-point dose-response curves starting at 20 uM. IC50 values...More data for this Ligand-Target Pair
Affinity DataEC50: 97nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 2.30E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 1.60E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 180nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 70nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 3.90E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 400nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 6.70E+3nMpH: 7.2 T: 2°CAssay Description:FRET-based co-activator recruitment assay measures agonist activities in a 384-well plate format. Reaction mixture containing His-tagged hLXR, biotin...More data for this Ligand-Target Pair