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Found 211 with Last Name = 'miyazaki' and Initial = 'y'
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50389606(CHEMBL2069625)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of human unphosphorylated N-terminal-His6 tagged VEGFR2 catalytic domain using 5-FAM-EEPLYWSFPAKKK-CONH2 as substrate after 60 mins by mob...More data for this Ligand-Target Pair
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5815(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5815(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  3nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8574(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-...)
Affinity DataIC50:  5nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5825(3-{4-[methyl({2-[(3-sulfamoylphenyl)amino]pyrimidi...)
Affinity DataIC50:  5nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50184499(CHEMBL208638 | N-(2-(3-(4-(aminomethyl)phenyl)prop...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8579(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 24 | N-[6-...)
Affinity DataIC50:  5nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15006(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[...)
Affinity DataIC50:  7.08nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15003(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[...)
Affinity DataIC50:  7.76nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15006(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[...)
Affinity DataIC50:  10.2nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15003(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[...)
Affinity DataIC50:  13.5nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5815(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  15.5nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50195876(3-(4-amino-3-{4-[3-(2-fluoro-5-trifluoromethyl-phe...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5819(3-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataIC50:  18nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195879(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,2-c...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5816(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM50373018(CHEMBL404507)
Affinity DataIC50:  23nMAssay Description:Inhibition of human GSK3-beta by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8575(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15010(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-n...)
Affinity DataIC50:  24.0nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5814(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM50373013(CHEMBL258081)
Affinity DataIC50:  30nMAssay Description:Inhibition of human GSK3-beta by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant GST-6XHis-VEGFR2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8563(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 8 | N-[6-(...)
Affinity DataIC50:  32nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5810(N-{3-[4-amino-5-(4-phenylphenyl)furo[2,3-d]pyrimid...)
Affinity DataIC50:  36nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195888(2-(3-(4-amino-3-(3-chloro-4-fluorophenyl)thieno[3,...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50195878(1-(4-(4-amino-7-phenylfuro[3,2-c]pyridin-3-yl)phen...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant GST-Tie2 by HTRF methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195877(3-(3-chloro-4-fluorophenyl)-7-(pyridin-3-yl)thieno...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM16127(2,2 -methanediylbis(1H-benzimidazole-6-carboximida...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5818(furo[2,3-d]pyrimidine deriv. 7n | {4-[4-amino-6-(4...)
Affinity DataIC50:  58nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5817(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  59nMpH: 7.5 T: 2°CAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195892(3-(3-chloro-4-fluorophenyl)-7-(3-(methylsulfonyl)p...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5814(3-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  62nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5808(N-{3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimi...)
Affinity DataIC50:  65nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50184504(CHEMBL380668 | N-(2-(3-(4-(aminomethyl)phenyl)prop...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8558(6-(4-methoxyphenyl)-5-(pyridin-3-yl)furo[2,3-d]pyr...)
Affinity DataIC50:  81nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15010(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-n...)
Affinity DataIC50:  81.3nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5821(phenyl N-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]...)
Affinity DataIC50:  95nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50195884(3-(3-chloro-4-fluorophenyl)-7-(3,4,5-trimethoxyphe...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human EphB4 by scintillation proximity methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5822(3-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataIC50:  117nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50184505(CHEMBL415045 | N-(2-((3-(4-(aminomethyl)phenyl)pro...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Tryptase beta-2(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50184508(CHEMBL207193 | N-(2-(3-(4-(aminomethyl)phenyl)prop...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human beta tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8561(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 6 | N-[6-(...)
Affinity DataIC50:  132nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15004(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[...)
Affinity DataIC50:  138nMpH: 7.5 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8570(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 15 | N-{6-...)
Affinity DataIC50:  174nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5820(N-{4-[(2-{[3-(methanesulfonylmethyl)phenyl]amino}p...)
Affinity DataIC50:  176nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM5806(3-[4-amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin...)
Affinity DataIC50:  180nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM15009(3-(4-{4-aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-n...)
Affinity DataIC50:  182nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-6x His-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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